Phenotypes associated with this allele

• Allele Symbol: Tg(Krt14-Nog)#Jake
• Allele Name: transgene insertion, John A Kessler
• Allele ID: MGI:4455044
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Krt14-Bmp4)#Jake/0 Tg(Krt14-Nog)#Jake/0	involves: BALB/c * C57BL/6 * FVB	MGI:4455048
tg2	Tg(Krt14-Nog)#Jake/0	FVB-Tg(Krt14-Nog)#Jake	MGI:4455045
tg3	Tg(Krt14-Nog)#Jake/0	involves: BALB/c * C57BL/6 * FVB	MGI:4455046

Genotype
MGI:4455048

cx1

• Allelic Composition: Tg(Krt14-Bmp4)#Jake/0; Tg(Krt14-Nog)#Jake/0
• Genetic Background: involves: BALB/c * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal upper incisor morphology ( J:156471 )

• grooves on the labial surface of maxillary incisors that are caused by loss of enamel

abnormal enamel morphology ( J:156471 )

• grooves on incisors result from a localized reduction of enamel on the labial surface

limbs/digits/tail

limbs/digits/tail phenotype ( J:78767 )

N • normal number and flexion of digits

interdigital webbing ( J:78767 )

• on the hindlimb, only a small web between digits II and III is seen unlike in Tg(Krt14-Nog)#Jake single transgenics

craniofacial

abnormal upper incisor morphology ( J:156471 )

• grooves on the labial surface of maxillary incisors that are caused by loss of enamel

abnormal enamel morphology ( J:156471 )

• grooves on incisors result from a localized reduction of enamel on the labial surface

growth/size/body

abnormal upper incisor morphology ( J:156471 )

• grooves on the labial surface of maxillary incisors that are caused by loss of enamel

abnormal enamel morphology ( J:156471 )

• grooves on incisors result from a localized reduction of enamel on the labial surface

Genotype
MGI:4455045

tg2

• Allelic Composition: Tg(Krt14-Nog)#Jake/0
• Genetic Background: FVB-Tg(Krt14-Nog)#Jake

limbs/digits/tail

abnormal interdigital cell death ( J:78767 )

• cell death in the necrotic zones is suppressed in forelimbs and hindlimbs at E13.5 and E14.5

abnormal apical ectodermal ridge morphology ( J:78767 )

• expression analysis suggests a delay in the regression of the AER at E12.5

brachydactyly ( J:78767 )

• on P2 mice show proportionally shortened digits

camptodactyly ( J:78767 )

• increased flexion of the digits of both the forelimb and the hindlimb

postaxial polydactyly ( J:78767 )

• a postaxial extradigit is seen in both the forelimb and the hindlimb

preaxial polydactyly ( J:78767 )

• an extra preaxial digit rudiment is sometimes seen in the hindlimb

syndactyly ( J:78767 )

• the syndactyly of adult forelimb is so pronounced that the digits can not be separated

• in newborns on the forelimbs and the hindlimbs the digits are incompletely separated

polysyndactyly ( J:78767 )

interdigital webbing ( J:78767 )

• seen at E14.5 and in adults

growth/size/body

slow postnatal weight gain ( J:78767 )

• equal in weight at birth but decreased weight gain over time

embryo

abnormal apical ectodermal ridge morphology ( J:78767 )

• expression analysis suggests a delay in the regression of the AER at E12.5

integument

abnormal coat/ hair morphology ( J:78767 )

• various abnormalities of hair follicles

abnormal vibrissa morphology ( J:78767 )

• various abnormalities in vibrissae

cellular

abnormal interdigital cell death ( J:78767 )

• cell death in the necrotic zones is suppressed in forelimbs and hindlimbs at E13.5 and E14.5

Genotype
MGI:4455046

tg3

• Allelic Composition: Tg(Krt14-Nog)#Jake/0
• Genetic Background: involves: BALB/c * C57BL/6 * FVB

limbs/digits/tail

abnormal interdigital cell death ( J:78767 )

• cell death in the necrotic zones is suppressed in forelimbs and hindlimbs at E13.5 and E14.5

brachydactyly ( J:78767 )

• on P2 mice show proportionally shortened digits

camptodactyly ( J:78767 )

• increased flexion of the digits of both the forelimb and the hindlimb

postaxial polydactyly ( J:78767 )

• a postaxial extradigit is seen in both the forelimb and the hindlimb

preaxial polydactyly ( J:78767 )

• an extra preaxial digit rudiment is sometimes seen in the hindlimb

syndactyly ( J:78767 )

• the syndactyly of adult forelimb is so pronounced that the digits can not be separated

• in newborns on the forelimbs and the hindlimbs the digits are incompletely separated

polysyndactyly ( J:78767 )

interdigital webbing ( J:78767 )

• seen at E14.5 and in adults

cellular

abnormal interdigital cell death ( J:78767 )

• cell death in the necrotic zones is suppressed in forelimbs and hindlimbs at E13.5 and E14.5