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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4ratm3.1Tch
targeted mutation 3.1, Talal A Chatila
MGI:4455123
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il4ratm3.1Tch/Il4ratm3.1Tch C.129X1-Il4ratm3.1Tch MGI:4455178


Genotype
MGI:4455178
hm1
Allelic
Composition		 Il4ratm3.1Tch/Il4ratm3.1Tch
Genetic
Background		 C.129X1-Il4ratm3.1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm3.1Tch mutation (1 available); any Il4ra mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgE level ( J:160806 )
• following immunization with ovalbumin and alum adjuvant
abnormal macrophage activation involved in immune response ( J:160806 )
• following exposure to IL4 and IL13, marker expression reveals enhanced alternative macrophage activation compared to in wild-type mice
increased susceptibility to type I hypersensitivity reaction ( J:160806 )
• following airway ovalbumin sensitization, mice exhibit an increased accumulation of eosinophils in the bronchoalveolar lavage fluid compared with similarly treated wild-type mice

hematopoietic system
increased IgE level ( J:160806 )
• following immunization with ovalbumin and alum adjuvant
abnormal macrophage activation involved in immune response ( J:160806 )
• following exposure to IL4 and IL13, marker expression reveals enhanced alternative macrophage activation compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory