Phenotypes associated with this allele

• Allele Symbol: Tg(Neurog1-cre)1Jejo
• Allele Name: transgene insertion 1, Jane E Johnson
• Allele ID: MGI:4455179
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mafb^tm1.1Good/Mafb^tm1Jeng Tg(Neurog1-cre)1Jejo/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:5581687
cn2	Gt(ROSA)26Sor^tm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor^+ Tg(Neurog1-cre)1Jejo/0	involves: 129S4/SvJae * C57BL/6J * SJL/J	MGI:5581688
cn3	Chd7^Gt(S20-7E1)Sor/Chd7^tm1.1Dmm Gt(ROSA)26Sor^tm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor^+ Tg(Neurog1-cre)1Jejo/0	involves: 129S * C57BL/6 * SJL/J	MGI:7518675

Genotype
MGI:5581687

cn1

• Allelic Composition: Mafb^tm1.1Good/Mafb^tm1Jeng; Tg(Neurog1-cre)1Jejo/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:207904 )

N • mice survive through adulthood

nervous system

nervous system phenotype ( J:207904 )

N • spiral ganglion neuron (SGN) processes organization and density are normal

N • efferent innervation of cochlea is normal

N • SGN firing properties are normal

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• some are abnormally small or misshapen

• reduced numbers at P15

abnormal cochlear ganglion morphology ( J:207904 )

• failure of post-synpatic differentiation near the basolateral pole of the inner hair cells by P6

• impaired presynaptic development

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:207904 )

N • distortion product otoacoustic emissions are normal

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• some are abnormally small or misshapen

• reduced numbers at P15

increased or absent threshold for auditory brainstem response ( J:207904 )

• dampened auditory brainstem response (ABR) waveforms and elevated auditory thresholds

• ABR wave I is delayed with increased latency compared to in control mice

Genotype
MGI:5581688

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Mafb,-tdTomato)Good}/Gt(ROSA)26Sor⁺; Tg(Neurog1-cre)1Jejo/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

mortality/aging

postnatal lethality, incomplete penetrance ( J:207904 )

• most mice die at 3 weeks of age of unknown causes

nervous system

nervous system phenotype ( J:207904 )

N • cochlear wiring and in spiral ganglion neuron firing properties are normal

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• precocious basolateral localization of pre-synaptic ribbons in the hair cells

• however, the number of ribbons is normal

abnormal cochlear ganglion morphology ( J:207904 )

• afferent synapse development is accelerated in spiral ganglion neuron compared to in control mice

hearing/vestibular/ear

abnormal inner hair cell synaptic ribbon morphology ( J:207904 )

• precocious basolateral localization of pre-synaptic ribbons in the hair cells

• however, the number of ribbons is normal

Genotype
MGI:7518675

cn3

• Allelic Composition: Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm; Gt(ROSA)26Sor^{tm6(CAG-ZsGreen1)Hze}/Gt(ROSA)26Sor⁺; Tg(Neurog1-cre)1Jejo/0
• Genetic Background: involves: 129S * C57BL/6 * SJL/J

nervous system

abnormal vestibulocochlear ganglion morphology ( J:310063 )

• in the apical region of the cochlea aberrant axonal projections that cross, loop, and extend beyond the epithelium are seen

• at P1 total area of the spiral ganglion is reduced