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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Megf8m687Ddg
mutation 687, David D Ginty
MGI:4455205
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Megf8m687Ddg/Megf8m687Ddg involves: C3H/He * C57BL/6 MGI:4455317
ht2
 		Megf8Gt(G037A09)Wrst/Megf8m687Ddg involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J MGI:5558936


Genotype
MGI:4455317
hm1
Allelic
Composition		 Megf8m687Ddg/Megf8m687Ddg
Genetic
Background		 involves: C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8m687Ddg mutation (1 available); any Megf8 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:159834 )
• mice exhibit abnormal development and patterning of the peripheral nervous system compared with wild-type mice
abnormal axon fasciculation ( J:159834 , J:206541 )
• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice (J:159834)
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face (J:206541)
abnormal trigeminal nerve morphology ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face
• however, the maxillary and mandibular branches are largely unaffected
abnormal ophthalmic nerve morphology ( J:159834 , J:206541 )
• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice (J:159834)
• axons within defasciculated bundles occupy a loosely defined tract and spread out prematurely within the face unlike in wild-type mice (J:159834)
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face (J:206541)

cellular
abnormal axon fasciculation ( J:159834 , J:206541 )
• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice (J:159834)
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face (J:206541)




Genotype
MGI:5558936
ht2
Allelic
Composition		 Megf8Gt(G037A09)Wrst/Megf8m687Ddg
Genetic
Background		 involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8Gt(G037A09)Wrst mutation (0 available); any Megf8 mutation (97 available)
Megf8m687Ddg mutation (1 available); any Megf8 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon fasciculation ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face
abnormal trigeminal nerve morphology ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face
• however, the maxillary and mandibular branches are largely unaffected
abnormal ophthalmic nerve morphology ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face

cellular
abnormal axon fasciculation ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory