Analysis Tools
mortality/aging
| N |
• mice are born in normal Mendelian ratios
|
reproductive system
 |
• hypoplastic
|
|
|
• mice have few mature graafian follicles
|
|
|
• mice exhibit immature endometrial epithelium compared with wild-type mice
|
|
|
• mice exhibit little glandular development compared with wild-type mice
|
|
|
• following hormone treatment, more eggs are released compared to in similarly treated wild-type mice
|
|
|
• irregular with prolonged diesterus and proesterus and shortened estrus
|
short estrus
(
J:157350
)
|
|
|
|
|
• breeding of female mice is largely unsuccessful compared with wild-type mice
|
|
• from female mice
|
homeostasis/metabolism
| N |
• mice exhibit normal fasting glucose and glucose clearance
|
|
• mice exhibit a tend towards reduced serum insulin levels compared with wild-type mice
|
|
• mice exhibit increased endocrine IGF-I levels compared with wild-type mice
|
|
• 3-fold from 2 to 16 weeks of age
|
growth/size/body
|
• at birth, mice are smaller than wild-type mice
• however, body weight is normalized by 2 weeks of age
|
|
• at 4 weeks of age, mice exhibit decreased body length compared with wild-type mice
• however, body length is normalized later on during growth and femur length is normal at 16 weeks of age
|
adipose tissue
|
• at 4 but not 8 weeks
|
|
• at 4 and 8 weeks but not 16 weeks
|
hematopoietic system
endocrine/exocrine glands
|
|
• mice exhibit increased ductal branching compared to in wild-type mice
|
|
|
• mice exhibit little glandular development compared with wild-type mice
|
|
|
• hypoplastic
|
|
|
• mice have few mature graafian follicles
|
immune system
integument
|
|
• mice exhibit increased ductal branching compared to in wild-type mice
|
