Phenotypes associated with this allele

• Allele Symbol: Pnn^tm1.1Sps
• Allele Name: targeted mutation 1.1, Stephen P Sugrue
• Allele ID: MGI:4455341
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pnn^tm1.1Sps/Pnn^tm1.2Sps Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S4/SvJae * FVB	MGI:4455346

Genotype
MGI:4455346

cn1

• Allelic Composition: Pnn^tm1.1Sps/Pnn^tm1.2Sps; Tg(Pax6-cre,GFP)1Pgr/0
• Genetic Background: involves: 129S4/SvJae * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:160411 )

N • no changes in proliferation or apoptosis are detected in the eye

irregularly shaped pupil ( J:160411 )

abnormal cornea morphology ( J:160411 )

• severely disorganized

• accumulation of mesenchymal and vascular cells in the posterior area of the cornea

• expression analysis indicates squamous metaplasia with loss of specific corneal epithelial identity

abnormal cornea stroma morphology ( J:160411 )

• increased cellularity and abnormal cellular arrangements at E14.5

abnormal lens morphology ( J:160411 )

• lens degeneration

microphthalmia ( J:160411 )