mortality/aging
• slightly fewer embryos than expected are recovered at E3.5 and none are recovered after implantation
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Allele Symbol Allele Name Allele ID |
Pnntm1.2Sps targeted mutation 1.2, Stephen P Sugrue MGI:4455342 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• slightly fewer embryos than expected are recovered at E3.5 and none are recovered after implantation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos found at E9.5 are severely defective and do not appear to have undergone gastrulation
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• embryos found at E9.5 do not appear to have undergone gastrulation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• no changes in proliferation or apoptosis are detected in the eye
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• severely disorganized
• accumulation of mesenchymal and vascular cells in the posterior area of the cornea
• expression analysis indicates squamous metaplasia with loss of specific corneal epithelial identity
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• increased cellularity and abnormal cellular arrangements at E14.5
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• lens degeneration
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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