Phenotypes associated with this allele

• Allele Symbol: Scaper^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4455688
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scaper^tm1a(EUCOMM)Hmgu/Scaper^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6460114

Genotype
MGI:6460114

hm1

• Allelic Composition: Scaper^{tm1a(EUCOMM)Hmgu}/Scaper^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0654_7_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:294607 )

♂ • no signs of spermatogenesis at 1 and 7 months of age

decreased primordial ovarian follicle number ( J:294607 )

♀ • at 1 month of age

decreased tertiary ovarian follicle number ( J:294607 )

♀ • at 1 month of age

increased atretic ovarian follicle number ( J:294607 )

♀ • increase in the number of atretic follicles

abnormal seminiferous tubule morphology ( J:294607 )

♂ • tubules are full of vacuoles at 1 and 7 months of age

♂ • tubules are composed of an irregular single-cell layer

small seminiferous tubules ( J:294607 )

♂ • thin at 1 and 7 months of age

small testis ( J:294607 )

♂ • reduced in both size and weight

decreased testis weight ( J:294607 )

♂

reduced female fertility ( J:294607 )

♀

decreased litter size ( J:294607 )

♀ • females produce smaller litters when crossed to wild-type males

male infertility ( J:294607 )

♂

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:294607 )

♀ • at 1 month of age

decreased tertiary ovarian follicle number ( J:294607 )

♀ • at 1 month of age

increased atretic ovarian follicle number ( J:294607 )

♀ • increase in the number of atretic follicles

abnormal seminiferous tubule morphology ( J:294607 )

♂ • tubules are full of vacuoles at 1 and 7 months of age

♂ • tubules are composed of an irregular single-cell layer

small seminiferous tubules ( J:294607 )

♂ • thin at 1 and 7 months of age

small testis ( J:294607 )

♂ • reduced in both size and weight

decreased testis weight ( J:294607 )

♂

cellular

azoospermia ( J:294607 )

♂ • no signs of spermatogenesis at 1 and 7 months of age