Phenotypes associated with this allele

• Allele Symbol: Crygn^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4455953
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Crygn^tm1a(EUCOMM)Wtsi/Crygn^tm1a(EUCOMM)Wtsi Egr2^tm2(cre)Pch/Egr2^+	involves: 129S2/SvPas * C57BL/6N	MGI:5903403

Genotype
MGI:5903403

cn1

• Allelic Composition: Crygn^{tm1a(EUCOMM)Wtsi}/Crygn^{tm1a(EUCOMM)Wtsi}; Egr2^tm2(cre)Pch/Egr2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:236916 )

N • mice exhibit no gross abnormalities in size or shape of all major nuclei of the superior olivary complex

abnormal pons morphology ( J:236916 )

• reduced volume of the medial nucleus of the trapezoid body (MNTB) at P25 due to reduced neuron numbers without a reduction in cross sectional area

• small reduction in the lateral superior olive

• however, MNTB volume is normal at P4

decreased neuron number ( J:236916 )

• in the medial nucleus of the trapezoid body

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:236916 )

N • mice exhibit a non-significant improvement in ABR thresholds for click and noise burst stimuli and DPOAE growth functions, amplitudes and thresholds

abnormal auditory brainstem response ( J:236916 )

• amplitudes of wave IV are increased above 50 dB compared with controls

• however, overall latencies of ABR peaks are normal