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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm7.1Xu
targeted mutation 7.1, Yang Xu
MGI:4456121
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm7.1Xu/Trp53tm7.1Xu Not Specified MGI:4456124
ht2
 		Trp53tm7.1Xu/Trp53+ Not Specified MGI:4456125
ht3
 		Trp53tm1Holl/Trp53tm7.1Xu involves: 129P2/OlaHsd MGI:4456126


Genotype
MGI:4456124
hm1
Allelic
Composition		 Trp53tm7.1Xu/Trp53tm7.1Xu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm7.1Xu mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:160414 )
• mice die within 6 months of cancer with the similar kinetics as null mice

neoplasm
increased tumor incidence ( J:160414 )
• mice die within 6 months of cancer with the similar kinetics as null mice
• tumor spectrum is more complex than in null mice
• mice develop thymic tumors, sarcomas, peripheral lymphomas, and germ cell tumors

cellular
abnormal cell cycle checkpoint function ( J:160414 )
• following irradiation, mouse embryonic fibroblasts and thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells
decreased thymocyte apoptosis ( J:160414 )
• following irradiation
chromosomal instability ( J:160414 )
• interchromosomal translocation are observed in pre-tumor thymocytes unlike in wild-type cells

immune system
abnormal thymus physiology ( J:160414 )
• following irradiation, thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells
decreased thymocyte apoptosis ( J:160414 )
• following irradiation

hematopoietic system
abnormal thymus physiology ( J:160414 )
• following irradiation, thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells
decreased thymocyte apoptosis ( J:160414 )
• following irradiation

endocrine/exocrine glands
abnormal thymus physiology ( J:160414 )
• following irradiation, thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells
decreased thymocyte apoptosis ( J:160414 )
• following irradiation




Genotype
MGI:4456125
ht2
Allelic
Composition		 Trp53tm7.1Xu/Trp53+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm7.1Xu mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle checkpoint function ( J:160414 )
• following irradiation, mouse embryonic fibroblasts and thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells
chromosomal instability ( J:160414 )
• interchromosomal translocation are observed thymocytes unlike in wild-type cells

immune system
abnormal thymus physiology ( J:160414 )
• following irradiation, thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells

hematopoietic system
abnormal thymus physiology ( J:160414 )
• following irradiation, thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells

endocrine/exocrine glands
abnormal thymus physiology ( J:160414 )
• following irradiation, thymocytes exhibit an impaired G2/M checkpoint compared with wild-type cells




Genotype
MGI:4456126
ht3
Allelic
Composition		 Trp53tm1Holl/Trp53tm7.1Xu
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (240 available)
Trp53tm7.1Xu mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes

neoplasm
increased tumor incidence ( J:160414 )
• tumorigenesis is partially rescued compared to in Trp53tm7Xu homozygotes with delayed onset and reduced penetrance

hematopoietic system
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes

cellular
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:160414 )
• following irradiation, thymocyte apoptosis is decreased compared to in wild-type mice but not as much as in homozygous Trp53tm7Xu thymocytes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory