About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdnftm1.1Neas
targeted mutation 1.1, Neil A Shneider
MGI:4456155
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gdnftm1.1Neas/Gdnftm1.1Neas
Myf5tm3(cre)Sor/Myf5+ 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL MGI:4456171
cn2
 		Gdnftm1.1Neas/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod 		involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL MGI:4456169
cn3
 		Gdnftm1Bbd/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3+ 		involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL MGI:4456170


Genotype
MGI:4456171
cn1
Allelic
Composition		 Gdnftm1.1Neas/Gdnftm1.1Neas
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (19 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice




Genotype
MGI:4456169
cn2
Allelic
Composition		 Gdnftm1.1Neas/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation (0 available); any Egr3 mutation (17 available)
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit a depletion in gamma-motor neurons at a similar time course as observed in Egr3tm1Jmi homozygotes

muscle
muscle phenotype ( J:160727 )
N
• mice exhibit normal muscle spindle morphology




Genotype
MGI:4456170
cn3
Allelic
Composition		 Gdnftm1Bbd/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation (0 available); any Egr3 mutation (17 available)
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (19 available)
Gdnftm1Bbd mutation (0 available); any Gdnf mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit selective loss of gamma-motor neurons compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory