Phenotypes associated with this allele

• Allele Symbol: Acd^tm1.1Cek
• Allele Name: targeted mutation 1.1, Catherine Keegan
• Allele ID: MGI:4456177
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acd^tm1.1Cek/Acd^tm1.1Cek	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * SJL	MGI:4456184

Genotype
MGI:4456184

cn1

• Allelic Composition: Acd^tm1.1Cek/Acd^tm1.1Cek
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome morphology ( J:160503 )

• mouse embryonic fibroblasts expressing cre exhibit a 2.5- to 3.5-fold increase in single stranded telomeric DNA compared with wild-type cells

• some mouse embryonic fibroblasts expressing cre exhibit fusion of sister and non-sister telomeres unlike in wild-type cells

polyploidy ( J:160503 )

• mouse embryonic fibroblasts expressing cre undergo endoreduplication unlike wild-type cells

abnormal cell physiology ( J:160503 )

• mouse embryonic fibroblasts expressing cre exhibit a growth defect compared with wild-type cells

early cellular replicative senescence ( J:160503 )

• in mouse embryonic fibroblasts expressing cre