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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fshrtm1Hht
targeted mutation 1, Ilpo Huhtaniemi
MGI:4456197
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fshrtm1Hht/Fshrtm1Hht involves: 129S7/SvEvBrd MGI:4456207
ht2
 		Fshrtm1Hht/Fshr+ involves: 129S7/SvEvBrd MGI:4456206


Genotype
MGI:4456207
hm1
Allelic
Composition		 Fshrtm1Hht/Fshrtm1Hht
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fshrtm1Hht mutation (0 available); any Fshr mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
ovary hemorrhage ( J:160015 )
• abundant hemorrhagic cysts in ovaries from the age of 2.5 months onwards
• hemorrhagic cysts in 50% (8/16) of the mice at 2-3 months of age
• hemorrhagic cysts in 48% (14/29) of the mice at 6-8 months of age
• hemorrhagic cysts in 38% (6/16) of the mice at 11-13 months of age

endocrine/exocrine glands
ovary hemorrhage ( J:160015 )
• abundant hemorrhagic cysts in ovaries from the age of 2.5 months onwards
• hemorrhagic cysts in 50% (8/16) of the mice at 2-3 months of age
• hemorrhagic cysts in 48% (14/29) of the mice at 6-8 months of age
• hemorrhagic cysts in 38% (6/16) of the mice at 11-13 months of age

cardiovascular system
ovary hemorrhage ( J:160015 )
• abundant hemorrhagic cysts in ovaries from the age of 2.5 months onwards
• hemorrhagic cysts in 50% (8/16) of the mice at 2-3 months of age
• hemorrhagic cysts in 48% (14/29) of the mice at 6-8 months of age
• hemorrhagic cysts in 38% (6/16) of the mice at 11-13 months of age




Genotype
MGI:4456206
ht2
Allelic
Composition		 Fshrtm1Hht/Fshr+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fshrtm1Hht mutation (0 available); any Fshr mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
ovary hemorrhage ( J:160015 )
• abundant hemorrhagic cysts in ovaries from the age of 2.5 months onwards
• hemorrhagic cysts in 25% (2/8) of the mice at 2-3 months of age
• hemorrhagic cysts in 29% (10/35) of the mice at 6-8 months of age
• hemorrhagic cysts in 38% (6/16) of the mice at 11-13 months of age

endocrine/exocrine glands
ovary hemorrhage ( J:160015 )
• abundant hemorrhagic cysts in ovaries from the age of 2.5 months onwards
• hemorrhagic cysts in 25% (2/8) of the mice at 2-3 months of age
• hemorrhagic cysts in 29% (10/35) of the mice at 6-8 months of age
• hemorrhagic cysts in 38% (6/16) of the mice at 11-13 months of age

cardiovascular system
ovary hemorrhage ( J:160015 )
• abundant hemorrhagic cysts in ovaries from the age of 2.5 months onwards
• hemorrhagic cysts in 25% (2/8) of the mice at 2-3 months of age
• hemorrhagic cysts in 29% (10/35) of the mice at 6-8 months of age
• hemorrhagic cysts in 38% (6/16) of the mice at 11-13 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory