Analysis Tools
reproductive system
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• hemorrhagic follicles in ovaries
• found in 33% (2/6) of the mice at 1 months of age
• found in 6.7% (2/30) of the mice at 2-3 months of age
• found in 54% (29/54) of the mice at 6-8 months of age
• found in 65% (24/37) of the mice at 11-13 months of age
• red blood cells infiltrating through the theca cell layer
• first hemorrhagic cysts visible at 28 days of age
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• increased proliferation of the granulosa cells and growth of primary follicles
• significantly higher proportion of Ki67-positive small follicles
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• glycogen-rich, periodic acid-Schiff (PAS)-stained interstitial cell hyperplasia with multinuclear cells in the ovaries of 6-month-old mice and in 1-yr-old mice, covering most of the stroma
• unusually thick surface epithelium close to the PAS-stained areas with cellular mesenchyme underneath
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• reduced number of primordial, primary, and secondary follicles in the ovaries at the age of 6 months
• normal numbers of preantral, early antral, and antral follicles
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• bilateral malignant ovarian tumor in one transgenic mice with regular estrous cycles (1/16)
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• unilateral teratomas in about 20% of the ovaries (11/58) of the females between 6 and 8 months of age
• mature benign cysts with several differentiated tissue types such as bone, cartilage, fat, neuronal, respiratory, intestinal, and keratin-like elements
• immature tissue with blastic mesenchyme or syncytiotrophoblast-like cells in three cases, suggestive of teratocarcinoma or chorioncarcinoma
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• occasionally unsuccessful ovulation shown by luteinized unruptured follicles
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• irregular estrous cycles in 63% (10/16) of the females more than or equal to 10 weeks of age, vs. 17% (1/6) of the wild-type controls
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• the cycles of the affected mice miss estrous phases
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• the cycles of the affected mice miss proestrous phases
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• seven of 10 acyclic transgenic mice show no signs of pregnancy and deliver no litters
• normal development of female mice such as timing of vaginal opening and urogenital distance
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• delay in the time to first pregnancy in 3 of 10 acyclic transgenic mice
• normal development of female mice such as timing of vaginal opening and urogenital distance
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• increased litter sizes in transgenic mice with regular estrous cycles (6/16), compared with wild-type females
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neoplasm
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• bilateral malignant ovarian tumor in one transgenic mice with regular estrous cycles (1/16)
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• unilateral teratomas in about 20% of the ovaries (11/58) of the females between 6 and 8 months of age
• mature benign cysts with several differentiated tissue types such as bone, cartilage, fat, neuronal, respiratory, intestinal, and keratin-like elements
• immature tissue with blastic mesenchyme or syncytiotrophoblast-like cells in three cases, suggestive of teratocarcinoma or chorioncarcinoma
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• pituitary tumors with elevated serum prolactin levels
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homeostasis/metabolism
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• absent of clusters of LHbeta-positive cells in the transgenic pituitary, versus common clusters of positive cells in the wild-type pituitary by immunohistochemical detection
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• most of cells are positive for PRL in the transgenic pituitary, versus distinct but not dominant in the anterior lobe of the wild-type pituitary by immunohistochemical detection
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cellular
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• increased proliferation of the granulosa cells in primary follicles
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• increased proliferation of the granulosa cells and growth of primary follicles
• significantly higher proportion of Ki67-positive small follicles
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endocrine/exocrine glands
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• hemorrhagic follicles in ovaries
• found in 33% (2/6) of the mice at 1 months of age
• found in 6.7% (2/30) of the mice at 2-3 months of age
• found in 54% (29/54) of the mice at 6-8 months of age
• found in 65% (24/37) of the mice at 11-13 months of age
• red blood cells infiltrating through the theca cell layer
• first hemorrhagic cysts visible at 28 days of age
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• increased proliferation of the granulosa cells and growth of primary follicles
• significantly higher proportion of Ki67-positive small follicles
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• age-related accumulation of foamy-looking multinucleated giant cells in the cortico-medullary junction of the virgin females replacing the x-zone
• foamy, multinuclear PAS-stained layer of lipofuscin-positive cells
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• increased anterior pituitary size in females older than 6 months
• adenomatous growth with multiple blood-filled cavities and abundant mitotic cells
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• virgin females with high serum PRL and E2 show advanced lobulo-alveolar growth of the mammary gland, typical for late pregnancy
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• glycogen-rich, periodic acid-Schiff (PAS)-stained interstitial cell hyperplasia with multinuclear cells in the ovaries of 6-month-old mice and in 1-yr-old mice, covering most of the stroma
• unusually thick surface epithelium close to the PAS-stained areas with cellular mesenchyme underneath
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• reduced number of primordial, primary, and secondary follicles in the ovaries at the age of 6 months
• normal numbers of preantral, early antral, and antral follicles
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• bilateral malignant ovarian tumor in one transgenic mice with regular estrous cycles (1/16)
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• unilateral teratomas in about 20% of the ovaries (11/58) of the females between 6 and 8 months of age
• mature benign cysts with several differentiated tissue types such as bone, cartilage, fat, neuronal, respiratory, intestinal, and keratin-like elements
• immature tissue with blastic mesenchyme or syncytiotrophoblast-like cells in three cases, suggestive of teratocarcinoma or chorioncarcinoma
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• pituitary tumors with elevated serum prolactin levels
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nervous system
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• increased anterior pituitary size in females older than 6 months
• adenomatous growth with multiple blood-filled cavities and abundant mitotic cells
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• pituitary tumors with elevated serum prolactin levels
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cardiovascular system
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• hemorrhagic follicles in ovaries
• found in 33% (2/6) of the mice at 1 months of age
• found in 6.7% (2/30) of the mice at 2-3 months of age
• found in 54% (29/54) of the mice at 6-8 months of age
• found in 65% (24/37) of the mice at 11-13 months of age
• red blood cells infiltrating through the theca cell layer
• first hemorrhagic cysts visible at 28 days of age
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integument
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• virgin females with high serum PRL and E2 show advanced lobulo-alveolar growth of the mammary gland, typical for late pregnancy
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