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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdia3Gt(RST003)Byg
gene trap RST003
MGI:4456212
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg involves: 129P2/OlaHsd MGI:5301864
hm2
Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:4456227


Genotype
MGI:5301864
hm1
Allelic
Composition
Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdia3Gt(RST003)Byg mutation (0 available); any Pdia3 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• thapsigargin-treated mouse embryonic fibroblasts exhibit enhanced store-operated calcium entry compared with wild-type cells




Genotype
MGI:4456227
hm2
Allelic
Composition
Pdia3Gt(RST003)Byg/Pdia3Gt(RST003)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdia3Gt(RST003)Byg mutation (0 available); any Pdia3 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at E13.5 and no mice are present after E13.5

cellular
• mouse embryonic fibroblasts (MEFs) exhibit minor changes in endoplasmic reticulum calcium ion capacity compared with wild-type cells
• MEFs exhibit a small increase in the unfolded protein response (UPR) compared with wild-type mice
• however, no increase in apoptosis is observed

embryo

growth/size/body





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory