Phenotypes associated with this allele

• Allele Symbol: Pdia3^{Gt(RST003)Byg}
• Allele Name: gene trap RST003
• Allele ID: MGI:4456212
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdia3^Gt(RST003)Byg/Pdia3^Gt(RST003)Byg	involves: 129P2/OlaHsd	MGI:5301864
hm2	Pdia3^Gt(RST003)Byg/Pdia3^Gt(RST003)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:4456227

Genotype
MGI:5301864

hm1

• Allelic Composition: Pdia3^{Gt(RST003)Byg}/Pdia3^{Gt(RST003)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:178553 )

• thapsigargin-treated mouse embryonic fibroblasts exhibit enhanced store-operated calcium entry compared with wild-type cells

Genotype
MGI:4456227

hm2

• Allelic Composition: Pdia3^{Gt(RST003)Byg}/Pdia3^{Gt(RST003)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:160036 )

• fewer than expected mice are present at E13.5 and no mice are present after E13.5

cellular

abnormal cell physiology ( J:160036 )

• mouse embryonic fibroblasts (MEFs) exhibit minor changes in endoplasmic reticulum calcium ion capacity compared with wild-type cells

• MEFs exhibit a small increase in the unfolded protein response (UPR) compared with wild-type mice

• however, no increase in apoptosis is observed

embryo

decreased embryo size ( J:160036 )

• at E12.5

growth/size/body

decreased embryo size ( J:160036 )

• at E12.5