Phenotypes associated with this allele

• Allele Symbol: Fpr2^tm1Rjf
• Allele Name: targeted mutation 1, Roderick J Flower
• Allele ID: MGI:4456271
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fpr2^tm1Rjf/Fpr2^tm1Rjf	involves: 129S/SvEv * C57BL/6	MGI:4456352

Genotype
MGI:4456352

hm1

• Allelic Composition: Fpr2^tm1Rjf/Fpr2^tm1Rjf
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage chemotaxis ( J:159658 )

• macrophages treated with formyl-Met-Leu-Phe (fMLP) or serum amyloid protein A (SAA) exhibit reduced chemotaxis compared with similarly treated wild-type cells

abnormal neutrophil physiology ( J:159658 )

• the ability of AnxA1, dexamethasone, peptide Ac2-26, LXA4, and Cpd43 to inhibit polymorphonuclear accumulation into murine dorsal air pouches inflamed with IL1b is reduced compared to in similarly treated wild-type mice

• AnxA1 fails to inhibit polymorphonuclear accumulation in the peritoneal fluid of mice treated with zymosan unlike in wild-type mice

• SAA fails to increase the number of cells recruited by IL1b compared to in similarly treated wild-type mice

increased susceptibility to induced arthritis ( J:159658 )

• the K/B x N serum provoked artherogenic response is exacerbated and prolonged compared to in similarly treated wild-type mice

increased acute inflammation ( J:159658 )

• carrageenan induces a 2.5-fold increase in paw swelling with a larger number of infiltrating leukocyte compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal response to injury ( J:159658 )

• following mesenteric ischemic-reperfusion injury, cell migration is increased compared to in similarly treated wild-type mice

• following mesenteric ischemic-reperfusion injury with longer reperfusion times, adherent and emigrated cells are increased compared to in similarly treated wild-type mice

skeleton

increased susceptibility to induced arthritis ( J:159658 )

• the K/B x N serum provoked artherogenic response is exacerbated and prolonged compared to in similarly treated wild-type mice

cellular

impaired macrophage chemotaxis ( J:159658 )

• macrophages treated with formyl-Met-Leu-Phe (fMLP) or serum amyloid protein A (SAA) exhibit reduced chemotaxis compared with similarly treated wild-type cells

hematopoietic system

impaired macrophage chemotaxis ( J:159658 )

• macrophages treated with formyl-Met-Leu-Phe (fMLP) or serum amyloid protein A (SAA) exhibit reduced chemotaxis compared with similarly treated wild-type cells

abnormal neutrophil physiology ( J:159658 )

• the ability of AnxA1, dexamethasone, peptide Ac2-26, LXA4, and Cpd43 to inhibit polymorphonuclear accumulation into murine dorsal air pouches inflamed with IL1b is reduced compared to in similarly treated wild-type mice

• AnxA1 fails to inhibit polymorphonuclear accumulation in the peritoneal fluid of mice treated with zymosan unlike in wild-type mice

• SAA fails to increase the number of cells recruited by IL1b compared to in similarly treated wild-type mice