Phenotypes associated with this allele

• Allele Symbol: Gmnn^tm1.1Kio
• Allele Name: targeted mutation 1.1, Dimitris Kioussis
• Allele ID: MGI:4456353
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gmnn^tm1.1Kio/Gmnn^tm1.2Kio Tg(CD2-icre)4Kio/0	involves: 129S4/SvJae * C57BL/10 * CBA/Ca	MGI:4456379

Genotype
MGI:4456379

cn1

• Allelic Composition: Gmnn^tm1.1Kio/Gmnn^tm1.2Kio; Tg(CD2-icre)4Kio/0
• Genetic Background: involves: 129S4/SvJae * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:159657 )

• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells

• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells

• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells

• however, T cells exhibit normal apoptosis and entry into S phase

decreased thymocyte number ( J:159657 )

decreased DN1 thymic pro-T cell number ( J:159657 )

• moderate

decreased DN4 thymocyte number ( J:159657 )

• moderate

decreased double-positive T cell number ( J:159657 )

• moderate

decreased CD4-positive, alpha-beta T cell number ( J:159657 )

• mice exhibit a reduction of CD4+, CD4+CD62L-, and CD4+CD44^hi cells compared with control mice

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:159657 )

decreased CD8-positive, alpha-beta T cell number ( J:159657 )

• mice exhibit a reduction of CD8+ and CD8+CD62L- cells compared with control mice

decreased memory T cell number ( J:159657 )

hematopoietic system

decreased T cell proliferation ( J:159657 )

• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells

• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells

• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells

• however, T cells exhibit normal apoptosis and entry into S phase

decreased thymocyte number ( J:159657 )

decreased DN1 thymic pro-T cell number ( J:159657 )

• moderate

decreased DN4 thymocyte number ( J:159657 )

• moderate

decreased double-positive T cell number ( J:159657 )

• moderate

decreased CD4-positive, alpha-beta T cell number ( J:159657 )

• mice exhibit a reduction of CD4+, CD4+CD62L-, and CD4+CD44^hi cells compared with control mice

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:159657 )

decreased CD8-positive, alpha-beta T cell number ( J:159657 )

• mice exhibit a reduction of CD8+ and CD8+CD62L- cells compared with control mice

decreased memory T cell number ( J:159657 )

endocrine/exocrine glands

decreased thymocyte number ( J:159657 )

decreased DN1 thymic pro-T cell number ( J:159657 )

• moderate

decreased DN4 thymocyte number ( J:159657 )

• moderate

cellular

decreased T cell proliferation ( J:159657 )

• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells

• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells

• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells

• however, T cells exhibit normal apoptosis and entry into S phase