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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gmnntm1.2Kio
targeted mutation 1.2, Dimitris Kioussis
MGI:4456373
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gmnntm1.2Kio/Gmnntm1.2Kio involves: 129S4/SvJae MGI:4456378
cn2
 		Gmnntm1.1Kio/Gmnntm1.2Kio
Tg(CD2-icre)4Kio/0 		involves: 129S4/SvJae * C57BL/10 * CBA/Ca MGI:4456379


Genotype
MGI:4456378
hm1
Allelic
Composition		 Gmnntm1.2Kio/Gmnntm1.2Kio
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gmnntm1.2Kio mutation (0 available); any Gmnn mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4456379
cn2
Allelic
Composition		 Gmnntm1.1Kio/Gmnntm1.2Kio
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gmnntm1.1Kio mutation (0 available); any Gmnn mutation (27 available)
Gmnntm1.2Kio mutation (0 available); any Gmnn mutation (27 available)
Tg(CD2-icre)4Kio mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:159657 )
• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells
• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells
• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells
• however, T cells exhibit normal apoptosis and entry into S phase
decreased CD4-positive, alpha-beta T cell number ( J:159657 )
• mice exhibit a reduction of CD4+, CD4+CD62L-, and CD4+CD44hi cells compared with control mice
decreased CD8-positive, alpha-beta T cell number ( J:159657 )
• mice exhibit a reduction of CD8+ and CD8+CD62L- cells compared with control mice

hematopoietic system
decreased T cell proliferation ( J:159657 )
• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells
• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells
• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells
• however, T cells exhibit normal apoptosis and entry into S phase
decreased CD4-positive, alpha-beta T cell number ( J:159657 )
• mice exhibit a reduction of CD4+, CD4+CD62L-, and CD4+CD44hi cells compared with control mice
decreased CD8-positive, alpha-beta T cell number ( J:159657 )
• mice exhibit a reduction of CD8+ and CD8+CD62L- cells compared with control mice

endocrine/exocrine glands

cellular
decreased T cell proliferation ( J:159657 )
• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells
• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells
• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells
• however, T cells exhibit normal apoptosis and entry into S phase




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory