Phenotypes associated with this allele

• Allele Symbol: Rr155^tm1.1Erpi
• Allele Name: targeted mutation 1.1, Eric Pinaud
• Allele ID: MGI:4456430
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr155^tm1.1Erpi/Rr155^tm1.1Erpi	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4456432

Genotype
MGI:4456432

hm1

• Allelic Composition: Rr155^tm1.1Erpi/Rr155^tm1.1Erpi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:160101 )

N • mice exhibit normal mature B cell numbers, V(D)J recombination, stimulated B cell proliferation, and in vivo Ig response to ovalbumin immunization

abnormal immunoglobulin level ( J:160101 )

• mice exhibit decreased serum levels of IgG2a and IgG1 compared with wild-type mice

• however, secretion of immunoglobulin from LPS-stimulated B cells is normal

decreased IgG1 level ( J:160101 )

decreased IgG2a level ( J:160101 )

hematopoietic system

abnormal immunoglobulin level ( J:160101 )

• mice exhibit decreased serum levels of IgG2a and IgG1 compared with wild-type mice

• however, secretion of immunoglobulin from LPS-stimulated B cells is normal

decreased IgG1 level ( J:160101 )

decreased IgG2a level ( J:160101 )