Analysis Tools|
Allele Symbol Allele Name Allele ID |
Il6ratm1.1Drew targeted mutation 1.1, Angela Drew MGI:4456449 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are present at weaning with only a few mice dying after birth
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| N |
• mice exhibit normal vertical exploratory activity (rearings)
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• in the hole-board test, mice exhibit increased number of unexplored squares and a tendency for defecation compared with control mice
• mice exhibit decreased time in the center of a plus maze compared with control mice
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• in the hole-board test, mice exhibit increased number of head dips but not time spent dipping their head compared with control mice
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| N |
• mice exhibit normal levels of gliosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal acute-phase response to turpentine challenge
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• acute-phase response to turpentine challenge is completely muted compared to in similarly treated wild-type mice
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| N |
• mice exhibit normal healing of large wounds
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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