Phenotypes associated with this allele

• Allele Symbol: Il6ra^tm1.2Drew
• Allele Name: targeted mutation 1.2, Angela Drew
• Allele ID: MGI:4456450
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il6ra^tm1.2Drew/Il6ra^tm1.2Drew	involves: C57BL/6 * C57BL/6N * FVB/N * SJL	MGI:4456457
cx2	Il6^tm1Kopf/Il6^tm1Kopf Il6ra^tm1.2Drew/Il6ra^tm1.2Drew	involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL	MGI:4456869

Genotype
MGI:4456457

hm1

• Allelic Composition: Il6ra^tm1.2Drew/Il6ra^tm1.2Drew
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal inflammatory response ( J:160966 )

• following carrageenan induced inflammation, mice exhibit impaired neutrophil resolution after 7 days and delayed macrophage infiltration compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal wound healing ( J:160966 )

• mice exhibit delayed re-epithelialization of small and large wounds is delayed compared to in wild-type mice

• mice exhibit deficits in the formation of granulation tissue at wounds compared with wild-type mice

• however, macroscopic wound closure rates are normal

Genotype
MGI:4456869

cx2

• Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf; Il6ra^tm1.2Drew/Il6ra^tm1.2Drew
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL

homeostasis/metabolism

abnormal wound healing ( J:160966 )

• mice exhibit delayed re-epithelialization of small and large wounds is delayed compared to in wild-type mice

• mice exhibit deficits in the formation of granulation tissue at wounds compared with wild-type mice

• however, macroscopic wound closure rates are normal