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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikzf2tm1.1Etms
targeted mutation 1.1, Ethan M Shevach
MGI:4456473
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikzf2tm1.1Etms/Ikzf2tm1.1Etms
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:4456861


Genotype
MGI:4456861
cn1
Allelic
Composition		 Ikzf2tm1.1Etms/Ikzf2tm1.1Etms
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf2tm1.1Etms mutation (2 available); any Ikzf2 mutation (41 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal regulatory T cell physiology ( J:160098 )
• regulatory T cells fail to respond to TCR stimulation or IL2 unlike wild-type cells
• however, regulatory T cells respond normally to anti-CD3 and IL2 and are as suppressive as wild-type regulatory T cells

hematopoietic system
abnormal regulatory T cell physiology ( J:160098 )
• regulatory T cells fail to respond to TCR stimulation or IL2 unlike wild-type cells
• however, regulatory T cells respond normally to anti-CD3 and IL2 and are as suppressive as wild-type regulatory T cells




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory