Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gfertm1(KOMP)Mbp targeted mutation 1, Mouse Biology Program, UC Davis MGI:4456605 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at day 3 post-PH, hepatic mitochondria display ultrastructural abnormalities
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• at day 3 after CCl4 injection, the ratio of mtDNA copy number to nDNA in hepatic mitochondria is markedly reduced relative to controls
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• following partial hepatectomy (PH), hepatic ATP levels are significantly reduced at day 3 post-PH relative to controls
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• at day 2 post-PH, hepatic DNA synthesis is significantly inhibited relative to wild-type controls, as determined by quantification of BrdU-positive cells
• following carbon tetrachloride (CCl4)-induced acute liver injury, BrdU incorporation into dividing hepatocytes is significantly reduced at day 3 after CCl4 injection relative to wild-type controls
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• at days 3 and 7 post-PH, liver regeneration is significantly inhibited relative to wild-type controls, as determined by percent liver recovery based on calculated liver weight and deduced by MRI analysis
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• at day 3 post-PH, hepatic mitochondria display ultrastructural abnormalities
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• at day 3 after CCl4 injection, the ratio of mtDNA copy number to nDNA in hepatic mitochondria is markedly reduced relative to controls
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• at day 3 post-PH, the number of hepatic mitochondrial cristae is reduced relative to controls
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• at day 3 post-PH, the number of hepatic mitochondria is significantly reduced relative to controls
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• at day 3 post-PH, swollen mitochondria with extensive degeneration or even loss of cristae are observed
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• at day 2 post-PH, hepatic DNA synthesis is significantly inhibited relative to wild-type controls, as determined by quantification of BrdU-positive cells
• following carbon tetrachloride (CCl4)-induced acute liver injury, BrdU incorporation into dividing hepatocytes is significantly reduced at day 3 after CCl4 injection relative to wild-type controls
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• mRNA and protein levels of mitochondrial transcription factor A (TFAM) and peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (PGC-1alpha) are significantly reduced relative to wild-type controls at day 4 post-PH or at day 3 after CCl4 injection, indicating impaired mitochondrial DNA biogenesis
• at day 3 after CCl4 injection, mitochondrial energy production is significantly reduced, as shown by reduced hepatic ATP content and significantly increased malondialdehyde (MDA) levels relative to controls
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• at day 3 post-PH, hepatic levels of malondialdehyde (MDA), a metabolite product of lipid peroxidation, are increased by 138% relative to controls
• similarly, at day 3 after CCl4 injection, hepatic MDA levels are increased by 136% relative to controls
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• excessive production of ROS in liver tissue after PH or CCl4-induced acute liver injury relative to controls
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• at day 3 post-PH, hepatic levels of malondialdehyde (MDA), a metabolite product of lipid peroxidation, are increased by 138% relative to controls
• similarly, at day 3 after CCl4 injection, hepatic MDA levels are increased by 136% relative to controls
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• following CCl4-induced acute liver injury, liver damage is significantly greater than that in wild-type controls, as determined by the size of necrotic areas at day 3 after CCl4 injection
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/15/2024 MGI 6.24 |
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