Analysis Tools
integument
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• auchene growth is terminated before formation of the single bend unlike in wild-type mice
• however, the first segment is normal
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• shorter, thinner, and more numerous than in wild-type mice
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• at the end of the first hair cycle, all hairs are shorter and thinner than in wild-type mice
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• the first segment of zigzag hairs is variable in length from 60% to 100% of wild-type hair length
• the second segment is reduced in length 50% to 60% compared to in wild-type mice
• the first and second segments are thinner than in wild-type mice
• zigzag hairs lack the third and fourth segment unlike in wild-type mice
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• duration of anagen is decreased compared to in wild-type mice
• hair follicles enter catagen prematurely compared to in wild-type mice
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• catagen onset occurs at P12 and is less synchronized than in wild-type mice
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• telogen begins earlier than in wild-type mice
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• 40 days after depilation, only sparse hair regenerate unlike in similarly treated wild-type mice
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• proliferation of matrix progenitor cells abutting the dermal papilla (MPADs) and their progeny is reduced compared to in wild-type mice
• mice fail to exhibit normal hair follicle regeneration compared with wild-type mice
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• the number of apoptotic cells averaged over all follicles is increased
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cellular
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• the number of apoptotic cells averaged over all follicles is increased
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