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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lcp1tm1Erjb
targeted mutation 1, Eric J Brown
MGI:4457016
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lcp1tm1Erjb/Lcp1tm1Erjb involves: 129X1/SvJ MGI:4457027


Genotype
MGI:4457027
hm1
Allelic
Composition		 Lcp1tm1Erjb/Lcp1tm1Erjb
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp1tm1Erjb mutation (0 available); any Lcp1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:161042 )
N
• mice exhibit normal white blood cell counts and numbers of polymorphonuclear neutrophils
abnormal neutrophil physiology ( J:161042 )
• polymorphonuclear neutrophils (PMNs) are unable to kill S. aureus unlike wild-type cells
• regardless of stimuli, PMNs exhibit defective adhesion-dependent respiratory burst compared with wild-type cells
• however, PMNs exhibit normal migration, adhesion, phagocytosis of S. aureus, secretion of primary granule contents, and nonadherent respiratory burst
abnormal macrophage physiology ( J:161042 )
• bone marrow-derived macrophages exhibit decreased adhesion-dependent secretion of IL1 compared with wild-type cells
decreased interleukin-1 secretion ( J:161042 )
• bone marrow-derived macrophages exhibit decreased adhesion-dependent secretion of IL1 compared with wild-type cells
increased susceptibility to bacterial infection ( J:161042 )
• mice are unable to control an S. aureus infection unlike wild-type mice
• polymorphonuclear neutrophils (PMNs) are unable to kill S. aureus unlike wild-type cells

hematopoietic system
abnormal neutrophil physiology ( J:161042 )
• polymorphonuclear neutrophils (PMNs) are unable to kill S. aureus unlike wild-type cells
• regardless of stimuli, PMNs exhibit defective adhesion-dependent respiratory burst compared with wild-type cells
• however, PMNs exhibit normal migration, adhesion, phagocytosis of S. aureus, secretion of primary granule contents, and nonadherent respiratory burst
abnormal macrophage physiology ( J:161042 )
• bone marrow-derived macrophages exhibit decreased adhesion-dependent secretion of IL1 compared with wild-type cells




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory