All Phenotypes Tmprss6<tm1Dgen> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmprss6^tm1Dgen
targeted mutation 1, Deltagene
MGI:4457116

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	B6.129P2-Tmprss6^tm1Dgen/Crl	MGI:4457129
hm2	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457133
ht3	Tmprss6^tm1Dgen/Tmprss6⁺	B6.129P2-Tmprss6^tm1Dgen/Crl	MGI:4457132
ht4	Tmprss6^tm1Dgen/Tmprss6⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457138
ht5	Tmprss6^hem8/Tmprss6^tm1Dgen	involves: C57BL/6 * C57BL/6J	MGI:5829240
cx6	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457137
cx7	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457135
cx8	Hjv^tm1Nca/Hjv⁺ Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457134

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	B6.129P2-Tmprss6^tm1Dgen/Crl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:160248 )

• fewer than expected mice are produced on a congenic C57BL/6 background unlike on a mixed background

hematopoietic system

increased spleen weight ( J:160248 )

• mice exhibit a trend toward increased spleen weight compared with wild-type mice

extramedullary hematopoiesis ( J:160248 )

• in the spleen

microcytic anemia ( J:160248 )

• by 8 weeks

abnormal erythrocyte morphology ( J:160248 )

decreased erythrocyte cell number ( J:160248 )

decreased hematocrit ( J:160248 )

decreased hemoglobin content ( J:160248 )

decreased mean corpuscular hemoglobin ( J:237155 )

• at 2 months of age

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 , J:237155 )

• at 2 months of age (J:237155)

increased red blood cell distribution width ( J:160248 )

reticulocytosis ( J:237155 )

• at 2 months of age

decreased spleen iron level ( J:160248 )

• mice exhibit a trend toward decreased spleen iron levels compared with wild-type mice

homeostasis/metabolism

increased circulating unsaturated transferrin level ( J:237155 )

• decreased transferrin saturations at 2 months of age

abnormal iron homeostasis ( J:237155 )

• increased liver hepcidin RNA levels at 2 months of age

• decreased liver Bmp6 and Tmprss6 RNA levels

• however, liver Id1 RNA levels are relatively unchanged

decreased spleen iron level ( J:160248 )

• mice exhibit a trend toward decreased spleen iron levels compared with wild-type mice

decreased circulating iron level ( J:160248 , J:237155 )

• by 8 weeks (J:160248)

• decreased serum iron levels at 2 months of age (J:237155)

• however, spleen iron levels are normal (J:237155)

decreased liver iron level ( J:160248 , J:237155 )

• at 2 months of age (J:237155)

liver/biliary system

decreased liver iron level ( J:160248 , J:237155 )

• at 2 months of age (J:237155)

growth/size/body

decreased body size ( J:160248 )

increased spleen weight ( J:160248 )

• mice exhibit a trend toward increased spleen weight compared with wild-type mice

immune system

increased spleen weight ( J:160248 )

• mice exhibit a trend toward increased spleen weight compared with wild-type mice

decreased spleen iron level ( J:160248 )

• mice exhibit a trend toward decreased spleen iron levels compared with wild-type mice

integument

alopecia ( J:160248 , J:237155 )

• mice develop truncal alopecia before weaning unlike wild-type mice (J:160248)

• body hair loss sparing the face (J:237155)

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:160248 )

N	• Background Sensitivity: mice on a mixed background are represented in Mendelian ratio unlike mice on a congenic C57BL/6 background

endocrine/exocrine glands

decreased pancreas iron level ( J:160248 )

• at 8 weeks

hematopoietic system

microcytic anemia ( J:160248 )

• at 8 weeks

decreased erythrocyte cell number ( J:160248 )

decreased hematocrit ( J:160248 )

decreased hemoglobin content ( J:160248 )

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

increased red blood cell distribution width ( J:160248 )

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit decreased liver, heart, pancreas, and skeletal muscle iron levels compared with wild-type mice

• however, spleen iron levels are normal

decreased heart iron level ( J:160248 )

• at 8 weeks

decreased pancreas iron level ( J:160248 )

• at 8 weeks

decreased liver iron level ( J:160248 )

• at 8 weeks

liver/biliary system

decreased liver iron level ( J:160248 )

• at 8 weeks

cardiovascular system

decreased heart iron level ( J:160248 )

• at 8 weeks

integument

alopecia ( J:160248 )

• mice develop truncal alopecia before weaning unlike wild-type mice

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6⁺
Genetic Background	B6.129P2-Tmprss6^tm1Dgen/Crl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

decreased spleen iron level ( J:160248 )

• slightly in pregnant mice compared with pregnant wild-type mice

homeostasis/metabolism

decreased spleen iron level ( J:160248 )

• slightly in pregnant mice compared with pregnant wild-type mice

decreased circulating iron level ( J:160248 )

• mice exhibit a trend toward decreased serum iron levels compared with wild-type mice

decreased liver iron level ( J:160248 )

• mice exhibit decreased hepatic iron levels compared with wild-type mice

liver/biliary system

decreased liver iron level ( J:160248 )

• mice exhibit decreased hepatic iron levels compared with wild-type mice

immune system

decreased spleen iron level ( J:160248 )

• slightly in pregnant mice compared with pregnant wild-type mice

cellular

maternal effect ( J:160248 )

• pup from heterozygous dams exhibit reduced hepatic iron levels compared with pups from wild-type mice

• however, pups from heterozygous dams exhibit normal hematologic and serum parameters

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

Allelic Composition	Tmprss6^hem8/Tmprss6^tm1Dgen
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^hem8 mutation (0 available); any Tmprss6 mutation (46 available)
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin ( J:237155 )

• at 2 months of age

decreased mean corpuscular volume ( J:237155 )

• at 2 months of age

reticulocytosis ( J:237155 )

• increased reticulocyte counts at 2 months of age

homeostasis/metabolism

increased circulating unsaturated transferrin level ( J:237155 )

• decreased transferrin saturations at 2 months of age

abnormal iron homeostasis ( J:237155 )

• increased liver hepcidin RNA levels at 2 months of age

decreased circulating iron level ( J:237155 )

• decreased serum iron levels at 2 months of age

decreased liver iron level ( J:237155 )

• at 2 months of age

liver/biliary system

decreased liver iron level ( J:237155 )

• at 2 months of age

Allelic Composition	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hjv^tm1Nca mutation (1 available); any Hjv mutation (19 available)
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit increased liver, heart, pancreas, and muscle iron levels compared with wild-type mice

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

hematopoietic system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

liver/biliary system

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

abnormal hepatocyte morphology ( J:160248 )

• hepatocytes exhibit increased iron accumulation compared with wild-type cells

immune system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

integument

integument phenotype ( J:160248 )

N	• mice retain full body hair

Allelic Composition	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit increased liver, heart, pancreas, and muscle iron levels compared with wild-type mice

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

hematopoietic system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

liver/biliary system

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

abnormal hepatocyte morphology ( J:160248 )

• hepatocytes exhibit increased iron accumulation compared with wild-type cells

immune system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

Allelic Composition	Hjv^tm1Nca/Hjv⁺ Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased pancreas iron level ( J:160248 )

• at 8 weeks

hematopoietic system

microcytic anemia ( J:160248 )

• at 8 weeks

decreased erythrocyte cell number ( J:160248 )

decreased hematocrit ( J:160248 )

decreased hemoglobin content ( J:160248 )

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

increased red blood cell distribution width ( J:160248 )

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit decreased liver, heart, pancreas, and skeletal muscle iron levels compared with wild-type mice

• however, spleen iron levels are normal

decreased heart iron level ( J:160248 )

• decreased at 8 weeks

decreased pancreas iron level ( J:160248 )

• at 8 weeks

decreased liver iron level ( J:160248 )

• at 8 weeks

liver/biliary system

decreased liver iron level ( J:160248 )

• at 8 weeks

cardiovascular system

decreased heart iron level ( J:160248 )

• decreased at 8 weeks

integument

sparse hair ( J:160248 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24