Phenotypes associated with this allele

• Allele Symbol: Mov10l1^tm1.2Eno
• Allele Name: targeted mutation 1.2, Eric N Olson
• Allele ID: MGI:4457261
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mov10l1^tm1.2Eno/Mov10l1^tm1.2Eno	involves: 129S/SvEv * C57BL/6	MGI:4457274

Genotype
MGI:4457274

hm1

• Allelic Composition: Mov10l1^tm1.2Eno/Mov10l1^tm1.2Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:161124 )

N • female mice exhibit normal fertility

azoospermia ( J:161124 )

♂ • mice lack elongating spermatids unlike wild-type mice

♂ • epididymides lack mature sperm unlike wild-type mice

abnormal spermatid morphology ( J:161124 )

♂ • mice lack elongating spermatids unlike wild-type mice

abnormal spermatocyte morphology ( J:161124 )

♂ • mice exhibit many round, pachytene-like spermatocytes with degenerating nuclei unlike wild-type mice

abnormal male meiosis ( J:161124 )

♂ • marker staining indicates that the synaptonemal complex does not assemble correctly in spermatocytes unlike in wild-type cells

arrest of male meiosis ( J:161124 )

♂ • before the pachytene stage

small seminiferous tubules ( J:161124 )

♂

seminiferous tubule degeneration ( J:161124 )

♂ • beginning at P15

decreased testis weight ( J:161124 )

♂ • at P19 and P24

abnormal male reproductive system physiology ( J:161124 )

♂ • primary spermatocytes exhibit activation of long terminal repeats (LTRs) and LINE-1 retrotransposons unlike in wild-type cells

increased male germ cell apoptosis ( J:161124 )

♂ • beginning at P15, some tubules show massive TUNEL staining of the most mature spermatocytes

male infertility ( J:161124 )

♂

endocrine/exocrine glands

small seminiferous tubules ( J:161124 )

♂

seminiferous tubule degeneration ( J:161124 )

♂ • beginning at P15

decreased testis weight ( J:161124 )

♂ • at P19 and P24

cellular

azoospermia ( J:161124 )

♂ • mice lack elongating spermatids unlike wild-type mice

♂ • epididymides lack mature sperm unlike wild-type mice

abnormal spermatid morphology ( J:161124 )

♂ • mice lack elongating spermatids unlike wild-type mice

abnormal spermatocyte morphology ( J:161124 )

♂ • mice exhibit many round, pachytene-like spermatocytes with degenerating nuclei unlike wild-type mice

abnormal male meiosis ( J:161124 )

♂ • marker staining indicates that the synaptonemal complex does not assemble correctly in spermatocytes unlike in wild-type cells

arrest of male meiosis ( J:161124 )

♂ • before the pachytene stage

increased male germ cell apoptosis ( J:161124 )

♂ • beginning at P15, some tubules show massive TUNEL staining of the most mature spermatocytes