Phenotypes associated with this allele

• Allele Symbol: Mov10l1^tm1.2Jw
• Allele Name: targeted mutation 1.2, Jeremy Wang
• Allele ID: MGI:4457276
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mov10l1^tm1.2Jw/Mov10l1^tm1.2Jw	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4457286

Genotype
MGI:4457286

hm1

• Allelic Composition: Mov10l1^tm1.2Jw/Mov10l1^tm1.2Jw
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:161125 )

N • female mice exhibit normal fertility

azoospermia ( J:161125 )

♂ • seminiferous tubules lack postmeiotic germ cells unlike in wild-type mice

abnormal male meiosis ( J:161125 )

♂ • synapsis fail to form unlike in wild-type cells

arrest of male meiosis ( J:161125 )

♂ • early in meiosis

abnormal DNA methylation during gametogenesis ( J:161125 )

• male germ cells exhibit demethylation and derepression of LINE1 and IAP retrotransposons unlike in wild-type cells

small testis ( J:161125 )

♂

decreased testis weight ( J:161125 )

♂

abnormal male reproductive system physiology ( J:161125 )

♂ • prenatal gonocytes in testes exhibit derepression of LINE1 and IAP retrotransposons unlike in wild-type cells

male infertility ( J:161125 )

♂

cellular

azoospermia ( J:161125 )

♂ • seminiferous tubules lack postmeiotic germ cells unlike in wild-type mice

abnormal male meiosis ( J:161125 )

♂ • synapsis fail to form unlike in wild-type cells

arrest of male meiosis ( J:161125 )

♂ • early in meiosis

abnormal DNA methylation during gametogenesis ( J:161125 )

• male germ cells exhibit demethylation and derepression of LINE1 and IAP retrotransposons unlike in wild-type cells

endocrine/exocrine glands

small testis ( J:161125 )

♂

decreased testis weight ( J:161125 )

♂