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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnm2tm1.1Pdc
targeted mutation 1.1, Pietro De Camilli
MGI:4457365
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnm2tm1.1Pdc/Dnm2tm1.1Pdc involves: 129S1/SvImJ * C57BL/6 * SJL MGI:4457368
cn2
 		Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 MGI:5705503
cn3
 		Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/SvImJ * C57BL/6 MGI:5705502
cn4
 		Dnm1tm1Pdc/Dnm1tm1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:4457370


Genotype
MGI:4457368
hm1
Allelic
Composition		 Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:161127 )
• mice are healthy and fertile




Genotype
MGI:5705503
cn2
Allelic
Composition		 Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (40 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (100 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (74 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:217533 )
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected

vision/eye
abnormal retina vasculature morphology ( J:217533 )
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected




Genotype
MGI:5705502
cn3
Allelic
Composition		 Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (40 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (100 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:217533 )
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice

vision/eye
abnormal retina vasculature morphology ( J:217533 )
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice
abnormal retina neuronal layer morphology ( J:217533 )
• insufficient separation of the inner and outer nuclear layers with fewer Pax6+ cells




Genotype
MGI:4457370
cn4
Allelic
Composition		 Dnm1tm1Pdc/Dnm1tm1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm1Pdc mutation (0 available); any Dnm1 mutation (40 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:161127 )
• following viral delivery of Cre, fibroblasts exhibit impaired clathrin-mediated endocytosis unlike wild-type cells with increased tubulated pits and tubules
• however, cell viability in culture is normal




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory