Phenotypes associated with this allele

• Allele Symbol: Adipor1^tm2Tka
• Allele Name: targeted mutation 2, Takashi Kadowaki
• Allele ID: MGI:4457490
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adipor1^tm2Tka/Adipor1^tm2Tka Tg(Ckmm-cre)5Khn/0	B6.Cg-Adipor1^tm2Tka Tg(Ckmm-cre)5Khn	MGI:4457491

Genotype
MGI:4457491

cn1

• Allelic Composition: Adipor1^tm2Tka/Adipor1^tm2Tka; Tg(Ckmm-cre)5Khn/0
• Genetic Background: B6.Cg-Adipor1^tm2Tka Tg(Ckmm-cre)5Khn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:159462 )

• mice exhibit lower muscle endurance in an involuntary physical exercise test compared with wild-type mice

decreased oxygen consumption ( J:159462 )

• in skeletal muscle

abnormal glucose homeostasis ( J:159462 )

increased circulating glucose level ( J:159462 )

• following glucose administration

increased circulating insulin level ( J:159462 )

• following glucose administration

insulin resistance ( J:159462 )

• muscles exhibit decreased insulin sensitivity compared with wild-type mice with decreased glucose disposal and glucose infusion rate

• however, treatment with resveratrol or two weeks of exercise ameliorates insulin resistance while treatment with MnTBAP produces a trend towards amelioration of insulin resistance

increased skeletal muscle triglyceride level ( J:159462 )

cellular

abnormal skeletal muscle fiber mitochondrial morphology ( J:159462 )

• skeletal muscle exhibits a decrease in mitochondrial DNA content compared with wild-type muscle

• however, treatment with resveratrol, Bay-K 8644 (a calcium-channel opener), or two weeks of exercise increased mitochondrial content

oxidative stress ( J:159462 )

• skeletal muscle cells exhibit a decrease in beta oxidation and an increased in hydrogen peroxide level compared with wild-type cells

• however, treatment with MnTBAP reduces hydrogen peroxide levels

muscle

abnormal skeletal muscle fiber mitochondrial morphology ( J:159462 )

• skeletal muscle exhibits a decrease in mitochondrial DNA content compared with wild-type muscle

• however, treatment with resveratrol, Bay-K 8644 (a calcium-channel opener), or two weeks of exercise increased mitochondrial content

increased skeletal muscle triglyceride level ( J:159462 )

abnormal skeletal muscle fiber type ratio ( J:159462 )

• soleus muscle exhibit a decrease in type I fibers compared with wild-type muscles

behavior/neurological

impaired exercise endurance ( J:159462 )

• mice exhibit lower muscle endurance in an involuntary physical exercise test compared with wild-type mice