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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Portm3Ding
targeted mutation 3, Xinxin Ding
MGI:4457492
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Portm3Ding/Portm3Ding C57BL/6-Portm3Ding MGI:4457493
hm2
 		Portm3Ding/Portm3Ding involves: C57BL/6 * DBA MGI:4457495
cn3
 		Portm3Ding/Portm3Ding
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA MGI:4457494


Genotype
MGI:4457493
hm1
Allelic
Composition		 Portm3Ding/Portm3Ding
Genetic
Background		 C57BL/6-Portm3Ding
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Portm3Ding mutation (1 available); any Por mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:159168 )
N
• male mice are fertile

homeostasis/metabolism

behavior/neurological
enhanced behavioral response to anesthetic ( J:159168 )
• pentobarbital-treated mice exhibit extended sleeping time compared with similarly treated wild-type mice

growth/size/body
decreased body weight ( J:159168 )
• in male and female mice

cardiovascular system
decreased heart weight ( J:159168 )
• in male mice

renal/urinary system
decreased kidney weight ( J:159168 )
• in male mice

respiratory system
decreased lung weight ( J:159168 )
• in male mice




Genotype
MGI:4457495
hm2
Allelic
Composition		 Portm3Ding/Portm3Ding
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Portm3Ding mutation (1 available); any Por mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:159168 )
• fewer than expected mice are produced (no time point given)




Genotype
MGI:4457494
cn3
Allelic
Composition		 Portm3Ding/Portm3Ding
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Portm3Ding mutation (1 available); any Por mutation (80 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:159168 )
N
• mice exhibit normal embryonic survival

reproductive system

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159168 )
N
• mice exhibit normal circulating cholesterol levels
abnormal enzyme/coenzyme activity ( J:159168 )
• NNK-treated mice exhibit reduced levels of DNA adduction (a measure of NKK activation) compared with similarly treated wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:159168 )
N
• mice exhibit normal sleeping time in response to pentobarbital treatment

growth/size/body
growth/size/body region phenotype ( J:159168 )
N
• mice exhibit normal body and organ weights




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory