Phenotypes associated with this allele

• Allele Symbol: Zbtb16^7t
• Allele Name: seven toes
• Allele ID: MGI:4457499
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb16^7t/Zbtb16^7t	involves: C3HeB/FeJ * C57BL/6J	MGI:4457500

Genotype
MGI:4457500

hm1

• Allelic Composition: Zbtb16^7t/Zbtb16^7t
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Limb and axial skeleton abnormalities in Zbtb16^7t/Zbtb16^7t mice

limbs/digits/tail

abnormal digit morphology ( J:160477 )

ectopic digits ( J:160477 )

• digit I to digit II transformation in hindlimb in 100% of the animal

• preaxial digit resembles digit V in 20% of the animal

oligodactyly ( J:160477 )

• digit I absence in 20% of the animal

polydactyly ( J:160477 )

• 100% penetrant polydactyly in hindlimbs

interdigital webbing ( J:160477 )

• in 20% of the animal between digits I and II

abnormal talus morphology ( J:160477 )

• talus to calcaneus transformation in 53% of the animal

abnormal hindlimb zeugopod morphology ( J:160477 )

• shortened zeugopod in 33% of the animal

abnormal fibula morphology ( J:160477 )

• separation of tibia and fibula in 47% of the animal

absent fibula ( J:160477 )

• in 33% of the animal

increased diameter of fibula ( J:160477 )

• in 40% of the animal

abnormal tibia morphology ( J:160477 )

• separation of tibia and fibula in 47% of the animal

• 40% of animals have tibias that are transformed into fibula-like structures

abnormal metatarsal bone morphology ( J:160477 )

• metatarsal bony outgrowths in 40% of the animal

fused metatarsal bones ( J:160477 )

• metatarsal fusion in 13% of the animal

skeleton

abnormal talus morphology ( J:160477 )

• talus to calcaneus transformation in 53% of the animal

abnormal long bone morphology ( J:160477 )

abnormal fibula morphology ( J:160477 )

• separation of tibia and fibula in 47% of the animal

absent fibula ( J:160477 )

• in 33% of the animal

increased diameter of fibula ( J:160477 )

• in 40% of the animal

abnormal tibia morphology ( J:160477 )

• separation of tibia and fibula in 47% of the animal

• 40% of animals have tibias that are transformed into fibula-like structures

abnormal metatarsal bone morphology ( J:160477 )

• metatarsal bony outgrowths in 40% of the animal

fused metatarsal bones ( J:160477 )

• metatarsal fusion in 13% of the animal

abnormal xiphoid process morphology ( J:160477 )

• malformed xiphoid process in 40% of the animal

increased rib number ( J:160477 )

• extra pairs of ribs (8th, 9th and 10th ribs) attached to sternum in 73% of the animal

• normal 13 thoracic vertebrae

sacral vertebral transformation ( J:160477 )

• homeotic transformation of sacral region in 53% of the animal

reproductive system

reproductive system phenotype ( J:160477 )

N • some mice exhibit Sertoli Cell only tubules (< 2% of tubules) but only at older ages (> 10 months). This can be compared with <1% in wild-type mice

N • no agametic tubules in young mice

N • normal testis size at all ages