Phenotypes associated with this allele

• Allele Symbol: Arglu1^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4457552
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arglu1^tm1a(EUCOMM)Hmgu/Arglu1^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6360683

Genotype
MGI:6360683

hm1

• Allelic Composition: Arglu1^{tm1a(EUCOMM)Hmgu}/Arglu1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:273438 )

• homozygous mutant embryos are detected at E9.0 and E9.5 but not at E12.5

embryo

embryonic growth retardation ( J:273438 )

• embryos show an overall developmental delay of ~0.5 days at E9.0 and E9.5

growth/size/body

embryonic growth retardation ( J:273438 )

• embryos show an overall developmental delay of ~0.5 days at E9.0 and E9.5

nervous system

increased brain apoptosis ( J:273438 )

• at E9.0 and E9.5, embryos show increased apoptosis in the developing brain, as shown by cleaved caspase-3 staining

cellular

increased brain apoptosis ( J:273438 )

• at E9.0 and E9.5, embryos show increased apoptosis in the developing brain, as shown by cleaved caspase-3 staining