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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmnatm6Lgf
targeted mutation 6, Loren G Fong
MGI:4457608
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lmnatm6Lgf/Lmnatm6Lgf involves: 129P2/OlaHsd MGI:4840109
hm2
 		Lmnatm6Lgf/Lmnatm6Lgf involves: 129P2/OlaHsd * C57BL/6 MGI:4457610
cx3
 		Lmnatm6Lgf/Lmnatm6Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5754491
cx4
 		Lmnatm6Lgf/Lmnatm6Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4457612
cx5
 		Lmnatm6Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4457613


Genotype
MGI:4840109
hm1
Allelic
Composition		 Lmnatm6Lgf/Lmnatm6Lgf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell nucleus morphology ( J:165928 )
• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice but less than in Lmnatm7Lgf homozygotes
• nuclear stiffness in fibroblasts is increased compared to cells from wild-type mice and Lmnatm7Lgf homozygotes




Genotype
MGI:4457610
hm2
Allelic
Composition		 Lmnatm6Lgf/Lmnatm6Lgf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:160705 )
• body weight of females are slightly but significantly lower than those of wild-type females




Genotype
MGI:5754491
cx3
Allelic
Composition		 Lmnatm6Lgf/Lmnatm6Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:220988 )
N
• mice do not exhibit intestinal abnormalities




Genotype
MGI:4457612
cx4
Allelic
Composition		 Lmnatm6Lgf/Lmnatm6Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:160705 )
• survival is worse than in Zmpste24 single mutants
premature death ( J:160705 )
• survival is worse than in Zmpste24 single mutants

growth/size/body
decreased body weight ( J:160705 )
• smaller than Zmpste24 single mutants




Genotype
MGI:4457613
cx5
Allelic
Composition		 Lmnatm6Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:160705 )
• survival is worse than in Zmpste24 single mutants
premature death ( J:160705 )
• survival is worse than in Zmpste24 single mutants

growth/size/body
decreased body weight ( J:160705 )
• smaller than Zmpste24 single mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory