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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17rbtm1Anjm
targeted mutation 1, Andrew N J McKenzie
MGI:4457616
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il17rbtm1Anjm/Il17rbtm1Anjm BALB/c-Il17rbtm1Anjm MGI:4457618
cx2
 		Il17rbtm1Anjm/Il17rbtm1Anjm
Il1rl1tm1Anjm/Il1rl1tm1Anjm 		involves: 129P2/OlaHsd * BALB/c MGI:4457620
cx3
 		Il13tm3.1Anjm/Il13+
Il17rbtm1Anjm/Il17rbtm1Anjm
Il1rl1tm1Anjm/Il1rl1tm1Anjm 		involves: 129P2/OlaHsd * BALB/c MGI:4457697
cx4
 		Il13tm3.1Anjm/Il13+
Il17rbtm1Anjm/Il17rbtm1Anjm 		involves: BALB/c * C57BL/6 MGI:4457694


Genotype
MGI:4457618
hm1
Allelic
Composition		 Il17rbtm1Anjm/Il17rbtm1Anjm
Genetic
Background		 BALB/c-Il17rbtm1Anjm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Anjm mutation (0 available); any Il17rb mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
increased susceptibility to parasitic infection ( J:159464 )
• in response to infection with the helminth parasite N. brasiliensis, mice expel their worms more slowly than wild types
• however, all worms are expelled by 20 days post infection

hematopoietic system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis




Genotype
MGI:4457620
cx2
Allelic
Composition		 Il17rbtm1Anjm/Il17rbtm1Anjm
Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Anjm mutation (0 available); any Il17rb mutation (42 available)
Il1rl1tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
increased susceptibility to parasitic infection ( J:159464 )
• in response to infection with the helminth parasite N. brasiliensis, worm expulsion is severely impaired and mice possess significant worm burden at 20 days post infection

hematopoietic system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis




Genotype
MGI:4457697
cx3
Allelic
Composition		 Il13tm3.1Anjm/Il13+
Il17rbtm1Anjm/Il17rbtm1Anjm
Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm3.1Anjm mutation (0 available); any Il13 mutation (30 available)
Il17rbtm1Anjm mutation (0 available); any Il17rb mutation (42 available)
Il1rl1tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

immune system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis




Genotype
MGI:4457694
cx4
Allelic
Composition		 Il13tm3.1Anjm/Il13+
Il17rbtm1Anjm/Il17rbtm1Anjm
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm3.1Anjm mutation (0 available); any Il13 mutation (30 available)
Il17rbtm1Anjm mutation (0 available); any Il17rb mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

immune system
decreased eosinophil cell number ( J:159464 )
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory