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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pold1tm1.1Bdp
targeted mutation 1.1, Bradley D Preston
MGI:4458032
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pold1tm1.1Bdp/Pold1tm1.1Bdp B6.129-Pold1tm1.1Bdp MGI:4366920
cx2
 		Pold1tm1.1Bdp/Pold1tm1.1Bdp
Poletm1.1Bdp/Poletm1.1Bdp 		B6.129-Poletm1.1Bdp Pold1tm1.1Bdp MGI:4366922
cx3
 		Mlh1tm1Rak/Mlh1tm1Rak
Pold1tm1.1Bdp/Pold1tm1.1Bdp 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J MGI:4366923
cx4
 		Msh2tm1Rak/Msh2tm1Rak
Pold1tm1.1Bdp/Pold1tm1.1Bdp 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J MGI:4366926


Genotype
MGI:4366920
hm1
Allelic
Composition		 Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic
Background		 B6.129-Pold1tm1.1Bdp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1.1Bdp mutation (0 available); any Pold1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:153684 )
• mice die before 15 months

neoplasm
increased intestinal adenocarcinoma incidence ( J:153684 )
• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice
increased intestinal adenoma incidence ( J:153684 )
• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice
increased skin tumor incidence ( J:153684 )
• 25% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice
increased lymphoma incidence ( J:153684 )
• 14% of mice develop nodal lymphomas compared with 6% of wild-type mice
increased T cell derived lymphoma incidence ( J:153684 )
• in 42% of mice unlike wild-type mice
increased lung tumor incidence ( J:153684 )
• 28% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

integument
increased skin tumor incidence ( J:153684 )
• 25% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:153684 )
• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice
increased intestinal adenoma incidence ( J:153684 )
• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

respiratory system
increased lung tumor incidence ( J:153684 )
• 28% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:153684 )
• in 42% of mice unlike wild-type mice

hematopoietic system
increased T cell derived lymphoma incidence ( J:153684 )
• in 42% of mice unlike wild-type mice

immune system
increased T cell derived lymphoma incidence ( J:153684 )
• in 42% of mice unlike wild-type mice




Genotype
MGI:4366922
cx2
Allelic
Composition		 Pold1tm1.1Bdp/Pold1tm1.1Bdp
Poletm1.1Bdp/Poletm1.1Bdp
Genetic
Background		 B6.129-Poletm1.1Bdp Pold1tm1.1Bdp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1.1Bdp mutation (0 available); any Pold1 mutation (63 available)
Poletm1.1Bdp mutation (0 available); any Pole mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:153684 )
• mice die before 6 months

neoplasm
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice
increased skin tumor incidence ( J:153684 )
• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

integument
increased skin tumor incidence ( J:153684 )
• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice

immune system
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice

hematopoietic system
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice




Genotype
MGI:4366923
cx3
Allelic
Composition		 Mlh1tm1Rak/Mlh1tm1Rak
Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1tm1Rak mutation (1 available); any Mlh1 mutation (44 available)
Pold1tm1.1Bdp mutation (0 available); any Pold1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4366926
cx4
Allelic
Composition		 Msh2tm1Rak/Msh2tm1Rak
Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Rak mutation (1 available); any Msh2 mutation (95 available)
Pold1tm1.1Bdp mutation (0 available); any Pold1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:153684 )
• no mice are present at weaning




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory