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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpgrtm1Wbrg
targeted mutation 1, Wolfgang Berger
MGI:4458091
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rpgrtm1Wbrg/Rpgrtm1Wbrg B6.129P2-Rpgrtm1Wbrg MGI:4458093
hm2
 		Rpgrtm1Wbrg/Rpgrtm1Wbrg C.129P2-Rpgrtm1Wbrg MGI:4458094
cx3
 		Rpe65450M/Rpe65450M
Rpgrtm1Wbrg/Rpgrtm1Wbrg 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:4458095


Genotype
MGI:4458093
hm1
Allelic
Composition		 Rpgrtm1Wbrg/Rpgrtm1Wbrg
Genetic
Background		 B6.129P2-Rpgrtm1Wbrg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpgrtm1Wbrg mutation (0 available); any Rpgr mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal photoreceptor inner segment morphology ( J:160802 )
• at 6 months, mice exhibit a trend towards reduced inner segment thickness compared with wild-type mice
abnormal photoreceptor outer segment morphology ( J:160802 )
• at 6 months, mice exhibit a trend towards reduced outer segment thickness compared with wild-type mice
thin retina outer nuclear layer ( J:160802 )
• a trend at 6 months of age
abnormal cone electrophysiology ( J:160802 )
• at 9 months of age, photopic b-waves are marginally reduced unlike in wild-type mice
abnormal rod electrophysiology ( J:160802 )
• from the age of 3 months onward, mice exhibit a slightly progressive loss of scotopic a-wave amplitude unlike wild-type mice
• as mice age, scotopic b-waves are more stable than in wild-type mice

nervous system
abnormal photoreceptor inner segment morphology ( J:160802 )
• at 6 months, mice exhibit a trend towards reduced inner segment thickness compared with wild-type mice
abnormal photoreceptor outer segment morphology ( J:160802 )
• at 6 months, mice exhibit a trend towards reduced outer segment thickness compared with wild-type mice




Genotype
MGI:4458094
hm2
Allelic
Composition		 Rpgrtm1Wbrg/Rpgrtm1Wbrg
Genetic
Background		 C.129P2-Rpgrtm1Wbrg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpgrtm1Wbrg mutation (0 available); any Rpgr mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:160802 )
N
• mice exhibit normal, strain-specific retinal degeneration
decreased retina cone cell number ( J:160802 )
• at 9 and 12 months, authors state that histology suggests a decrease in the number of cones compared with wild-type mice
abnormal cone electrophysiology ( J:160802 )
• at 1 month of age, photopic b-waves are reduced compared to in wild-type mice
abnormal rod electrophysiology ( J:160802 )
• at 1 month of age, mice exhibit reduced scotopic a-wave amplitude unlike wild-type mice
• as mice age, scotopic b-waves are more stable than in wild-type mice

nervous system
decreased retina cone cell number ( J:160802 )
• at 9 and 12 months, authors state that histology suggests a decrease in the number of cones compared with wild-type mice




Genotype
MGI:4458095
cx3
Allelic
Composition		 Rpe65450M/Rpe65450M
Rpgrtm1Wbrg/Rpgrtm1Wbrg
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpe65450M mutation (2 available); any Rpe65 mutation (52 available)
Rpgrtm1Wbrg mutation (0 available); any Rpgr mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:160802 )
• authors state that mice exhibit the same eye phenotype as observed when mice are backcrossed to BALB/c for 8 generations
abnormal eye physiology ( J:160802 )
• authors state that mice exhibit the same eye phenotype as observed when mice are backcrossed to BALB/c for 8 generations




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory