Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ehd1tm1.2Haba targeted mutation 1.2, Hamid Band MGI:4458098 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 11% instead of the expected 25% were homozygous at post-natal days 10-12
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Ehd1tm1.2Haba/Ehd1tm1.2Haba mice are small and males exhibit small testis
|
• higher frequency (about 25%) of death at or near birth
|
|
• 8% instead of the expected 25% are homozygous at post-natal days 10-12, when intercrossing heterozygous mice
• 29% (instead of 50% expected) of the mice survive to weaning age, when intercrossing heterozygous male with homozygous female mice
• several mice die due to unknown causes at age 3-4 weeks
|
|
• females display malocclusion (22%)
|
|
• homozygous mice that survive early neonatal lethality are smaller from birth to adulthood
|
|
• lower weights in both male and female mice starting from 3 weeks of age
|
 |
• delay in the normal maturation of spermatogonia as analyzed by chromatin condensation and cell size at post-natal day 10
|
|
|
• some seminiferous tubules contain a greater number of apoptotic-like dense bodies at post-natal day 10
|
|
|
• Sertoli cell only seminiferous tubules at day 30
|
|
|
• reduced testis weight starting from day 42, compared with wild-type mice
• normal seminal vesicle size
|
|
|
• epididymides lack sperm at day 42, and continue into adulthood
|
|
|
• abnormal acrosomal caps with asymmetric formations and punctate appearances at day 30
|
|
|
• stage X seminiferous tubules have elongated spermatids with abnormal orientation, shape and chromatin condensation at day 30
• delay in the maturation of elongated spermatids with a mixture of spermatids (step 9, 10, and 11) at day 30
• a mixture of elongated spermatids (steps 9-11) as well as misaligned elongated spermatids near the basement membrane
• clumping of spermatid heads in addition to fusion of large aggregates of residual bodies and cytoplasmic lobes that contained clumped spermatids in late stage VIII
• clumping of step 16 spermatids in membranous wheels and near the basement membrane in stage X
• step 16 spermatids with their heads and tails fused
• cytoplasm of step 16 spermatids fails to form cytoplasmic lobes and residual bodies
|
|
|
• delay in the normal maturation of pachytene spermatocytes as analyzed by chromatin condensation and cell size at post-natal day 10
|
|
|
• stage XII seminiferous tubules display abnormal cells in meiosis at day 30
|
|
|
• Sertoli cell phagocytosis of step 16 spermatids fails to be released
• clumping of spermatid heads in addition to fusion of large aggregates of residual bodies and cytoplasmic lobes that contained clumped spermatids in late stage VIII
|
|
|
• failure of spermiation and clumping of spermatid heads in addition to fusion of large aggregates of residual bodies and cytoplasmic lobes that contained clumped spermatids in late stage VIII
• elongated spermatids appeared in phagocytic, membranous wheels in late stage VIII
• the phagocytic wheel is encased by ectoplasmic specializations and contained the nuclei, acrosomes and tails of elongated spermatids
|
|
|
• spermatogenesis only appears normal prior to acrosome formation
|
|
• females display malocclusion (22%)
|
|
• congenital central cataracts
|
|
• rare
|
|
|
• Sertoli cell only seminiferous tubules at day 30
|
|
|
• reduced testis weight starting from day 42, compared with wild-type mice
• normal seminal vesicle size
|
|
• females display malocclusion (22%)
|
|
|
• epididymides lack sperm at day 42, and continue into adulthood
|
|
|
• abnormal acrosomal caps with asymmetric formations and punctate appearances at day 30
|
|
|
• stage X seminiferous tubules have elongated spermatids with abnormal orientation, shape and chromatin condensation at day 30
• delay in the maturation of elongated spermatids with a mixture of spermatids (step 9, 10, and 11) at day 30
• a mixture of elongated spermatids (steps 9-11) as well as misaligned elongated spermatids near the basement membrane
• clumping of spermatid heads in addition to fusion of large aggregates of residual bodies and cytoplasmic lobes that contained clumped spermatids in late stage VIII
• clumping of step 16 spermatids in membranous wheels and near the basement membrane in stage X
• step 16 spermatids with their heads and tails fused
• cytoplasm of step 16 spermatids fails to form cytoplasmic lobes and residual bodies
|
|
|
• delay in the normal maturation of pachytene spermatocytes as analyzed by chromatin condensation and cell size at post-natal day 10
|
|
|
• delay in the normal maturation of spermatogonia as analyzed by chromatin condensation and cell size at post-natal day 10
|
|
|
• stage XII seminiferous tubules display abnormal cells in meiosis at day 30
|
|
|
• some seminiferous tubules contain a greater number of apoptotic-like dense bodies at post-natal day 10
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
