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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Emu-Zfp521)1Homy
transgene insertion 1, Hiroaki Honda
MGI:4458205
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tcf3tm1(TCF3/HLF)Homy/Tcf3+
Tg(Emu-Zfp521)1Homy/0
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4458210
tg2
Tg(Emu-Zfp521)1Homy/0 Not Specified MGI:4458209


Genotype
MGI:4458210
cn1
Allelic
Composition
Tcf3tm1(TCF3/HLF)Homy/Tcf3+
Tg(Emu-Zfp521)1Homy/0
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1(TCF3/HLF)Homy mutation (0 available); any Tcf3 mutation (43 available)
Tg(Emu-Zfp521)1Homy mutation (1 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• within 6 months, pIpC-treated mice die of leukemia

neoplasm
• pIpC-treated mice develop acute B-lineage leukemia by 6 months of age unlike control mice




Genotype
MGI:4458209
tg2
Allelic
Composition
Tg(Emu-Zfp521)1Homy/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Emu-Zfp521)1Homy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit an increase in B cell precursors in the bone marrow compared with wild-type mice
• mice exhibit an increase in B cell precursors in the bone marrow compared with wild-type mice

neoplasm
N
• mice do not develop leukemia

hematopoietic system
N
• mice exhibit normal hematological phenotypes in the peripheral blood
• mice exhibit an increase in B cell precursors in the bone marrow compared with wild-type mice
• mice exhibit an increase in B cell precursors in the bone marrow compared with wild-type mice





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory