Phenotypes associated with this allele

• Allele Symbol: Uchl1^gad-2J
• Allele Name: gracile axonal dystrophy 2 Jackson
• Allele ID: MGI:4458326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uchl1^gad-2J/Uchl1^gad-2J	B6.Cg-Uchl1^gad-2J/GrsrJ	MGI:4460998

Genotype
MGI:4460998

hm1

• Allelic Composition: Uchl1^gad-2J/Uchl1^gad-2J
• Genetic Background: B6.Cg-Uchl1^gad-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:161692 )

behavior/neurological

abnormal locomotor coordination ( J:161692 )

• at 6 or 7 weeks of age the hind legs begin to show weakness characterized by limb grasping, dragging or splaying when walking

ataxia ( J:161692 )

paralysis ( J:161692 )

• loss of hind limb function progresses to paralysis and premature death

growth/size/body

weight loss ( J:161692 )

• a progressive loss in body weight begins at 12 weeks of age

nervous system

neurodegeneration ( J:161692 )

• one mouse at 21 weeks of age was assessed and found to have degeneration of long tracks in the spinal cord and extensive neurogenic atrophy in the hind leg