Phenotypes associated with this allele

• Allele Symbol: Braf^tm1Rima
• Allele Name: targeted mutation 1, Richard Marais
• Allele ID: MGI:4458346
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Braf^tm1Rima/Braf^+ Kras^tm4Tyj/Kras^+ Tg(Tyr-cre/ERT2)1Lru/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:4458349
cn2	Braf^tm1Rima/Braf^+ Tg(Tyr-cre/ERT2)1Lru/0	involves: C57BL/6 * DBA/2	MGI:4458350
cn3	Braf^tm1Rima/Braf^+ Tg(GFP/KRAS2/ALPP)1Brn/0 Tg(Tyr-cre/ERT2)1Lru/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:4458351

Genotype
MGI:4458349

cn1

• Allelic Composition: Braf^tm1Rima/Braf⁺; Kras^tm4Tyj/Kras⁺; Tg(Tyr-cre/ERT2)1Lru/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:161180 )

• within 6 months, tamoxifen-treated mice develop large, rapid growing oligo-pigmented tumors with ulceration unlike wild-type mice

• tumors in tamoxifen-treated mice are largely composed of spindle cells with malignancy features

pigmentation

hyperpigmentation ( J:161180 )

• within 2 to 3 months, tamoxifen-treated mice exhibit a darkening of the tails, ears, and paws compared with wild-type mice

Genotype
MGI:4458350

cn2

• Allelic Composition: Braf^tm1Rima/Braf⁺; Tg(Tyr-cre/ERT2)1Lru/0
• Genetic Background: involves: C57BL/6 * DBA/2

pigmentation

pigmentation phenotype ( J:161180 )

N • mice exhibit normal pigmentation and do not develop nevi

neoplasm

neoplasm ( J:161180 )

N • mice do not develop tumors

Genotype
MGI:4458351

cn3

• Allelic Composition: Braf^tm1Rima/Braf⁺; Tg(GFP/KRAS2/ALPP)1Brn/0; Tg(Tyr-cre/ERT2)1Lru/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

neoplasm

increased melanoma incidence ( J:161180 )

• tamoxifen-treated mice exhibit rapid onset of melanoma with a median onset at 2 months and 100% penetrance within 3 months