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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Braftm1Rima
targeted mutation 1, Richard Marais
MGI:4458346
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Braftm1Rima/Braf+
Krastm4Tyj/Kras+
Tg(Tyr-cre/ERT2)1Lru/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:4458349
cn2
 		Braftm1Rima/Braf+
Tg(Tyr-cre/ERT2)1Lru/0 		involves: C57BL/6 * DBA/2 MGI:4458350
cn3
 		Braftm1Rima/Braf+
Tg(GFP/KRAS2/ALPP)1Brn/0
Tg(Tyr-cre/ERT2)1Lru/0 		involves: C57BL/6 * DBA/2 * FVB/N MGI:4458351


Genotype
MGI:4458349
cn1
Allelic
Composition		 Braftm1Rima/Braf+
Krastm4Tyj/Kras+
Tg(Tyr-cre/ERT2)1Lru/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Rima mutation (0 available); any Braf mutation (60 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:161180 )
• within 6 months, tamoxifen-treated mice develop large, rapid growing oligo-pigmented tumors with ulceration unlike wild-type mice
• tumors in tamoxifen-treated mice are largely composed of spindle cells with malignancy features

pigmentation
hyperpigmentation ( J:161180 )
• within 2 to 3 months, tamoxifen-treated mice exhibit a darkening of the tails, ears, and paws compared with wild-type mice




Genotype
MGI:4458350
cn2
Allelic
Composition		 Braftm1Rima/Braf+
Tg(Tyr-cre/ERT2)1Lru/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Rima mutation (0 available); any Braf mutation (60 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:161180 )
N
• mice exhibit normal pigmentation and do not develop nevi

neoplasm
neoplasm ( J:161180 )
N
• mice do not develop tumors




Genotype
MGI:4458351
cn3
Allelic
Composition		 Braftm1Rima/Braf+
Tg(GFP/KRAS2/ALPP)1Brn/0
Tg(Tyr-cre/ERT2)1Lru/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Rima mutation (0 available); any Braf mutation (60 available)
Tg(GFP/KRAS2/ALPP)1Brn mutation (1 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased melanoma incidence ( J:161180 )
• tamoxifen-treated mice exhibit rapid onset of melanoma with a median onset at 2 months and 100% penetrance within 3 months




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory