Phenotypes associated with this allele

• Allele Symbol: Dact1^tm1Yegc
• Allele Name: targeted mutation 1, Ye-Guang Chen
• Allele ID: MGI:4458394
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dact1^tm1Yegc/Dact1^tm1Yegc	B6.129-Dact1^tm1Yegc	MGI:4458413

Genotype
MGI:4458413

hm1

• Allelic Composition: Dact1^tm1Yegc/Dact1^tm1Yegc
• Genetic Background: B6.129-Dact1^tm1Yegc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Urogenital defects and posterior malformation with a shorter notochord and vertebrae defects in Dact1^tm1Yegc/Dact1^tm1Yegc mice

mortality/aging

decreased survivor rate ( J:161177 )

• only one mouse survived to adulthood

neonatal lethality, incomplete penetrance ( J:161177 )

• nearly all mice die within 24 hours of birth

reproductive system

absent external female genitalia ( J:161177 )

♀

blind uterus ( J:161177 )

♀

hydrometra ( J:161177 )

♀ • in the single mouse to survive to adulthood

absent vagina ( J:161177 )

♀ • in the single mouse to survive to adulthood

absent external male genitalia ( J:161177 )

♂

abnormal vas deferens morphology ( J:161177 )

♂ • blind-ended

female infertility ( J:161177 )

♀ • the single female generated was infertile

skeleton

abnormal ilium morphology ( J:161177 )

abnormal vertebrae morphology ( J:161177 )

• mice exhibit abnormal lumbar vertebrae and coccyges compared with wild-type mice

• however, mice exhibit normal thoracic vertebrae

decreased caudal vertebrae number ( J:161177 )

• most caudal coccyges are absent unlike in wild-type mice

abnormal lumbar vertebrae morphology ( J:161177 )

• caudal lumbar vertebrae are malformed compared to in wild-type mice

• the space between lumbar vertebrae is slightly increased compared with wild-type mice

abnormal sacral vertebrae morphology ( J:161177 )

renal/urinary system

abnormal renal/urinary system morphology ( J:161177 )

• mice exhibit abnormal urogenital tracts compared with wild-type mice

abnormal kidney morphology ( J:161177 )

• from E12.5 to P0, mice exhibit kidney defects unlike wild-type mice

kidney cyst ( J:161177 )

• in the single mouse to survive to adulthood

hydronephrosis ( J:161177 )

• in 11 of 12 mice at E17

absent kidney ( J:161177 )

• in 1 of 19 mice

fused kidneys ( J:161177 )

• in 16 of 19 mice

single kidney ( J:161177 )

• in 2 of 19 mice

blind ureter ( J:161177 )

• ureters are blind-ended

short ureter ( J:161177 )

ureter hypoplasia ( J:161177 )

• ureters are too thin or too short to be identified

urethra atresia ( J:161177 )

absent urinary bladder ( J:161177 )

• in 18 of 19 mice

digestive/alimentary system

absent anus ( J:161177 )

abnormal hindgut morphology ( J:161177 )

• at E8.25, the hindgut diverticulum is disorganized compared to in wild-type mice

embryo

abnormal embryonic cloaca morphology ( J:161177 )

• at E10.5

abnormal primitive urogenital sinus morphology ( J:161177 )

• at E11.5

abnormal presomitic mesoderm morphology ( J:161177 )

• at E19, the presomitic mesoderm exhibits posterior malformation compared to in wild-type mice

abnormal notochord morphology ( J:161177 )

• twisted and truncated

truncated notochord ( J:161177 )

limbs/digits/tail

decreased caudal vertebrae number ( J:161177 )

• most caudal coccyges are absent unlike in wild-type mice

short tail ( J:161177 )

growth/size/body

decreased birth body size ( J:161177 )

kidney cyst ( J:161177 )

• in the single mouse to survive to adulthood