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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tectatm1.1Ogha
targeted mutation 1.1, John Oghalai
MGI:4458424
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tectatm1.1Ogha/Tectatm1.1Ogha involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA MGI:4458442
hm2
 		Tectatm1.1Ogha/Tectatm1.1Ogha involves: 129S7/SvEvBrd * CBA MGI:4458445
ht3
 		Tectatm1.1Ogha/Tecta+ involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA MGI:4458443
cx4
 		Slc26a5tm1Jnz/Slc26a5tm1Jnz
Tectatm1.1Ogha/Tectatm1.1Ogha 		involves: 129S7/SvEvBrd * CBA MGI:4458444
cx5
 		Slc26a5tm1Jnz/Slc26a5tm1Jnz
Tectatm1.1Ogha/Tecta+ 		involves: 129S7/SvEvBrd * CBA MGI:4458446


Genotype
MGI:4458442
hm1
Allelic
Composition		 Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm1.1Ogha mutation (1 available); any Tecta mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:160851 )
N
• mice exhibit normal vestibular function
abnormal tectorial membrane morphology ( J:160851 )
• the tectorial membrane is thicker and shorter than in wild-type and heterozygous mice
• the shortened tectorial membrane does not cover all three rows of the outer hair cells unlike in wild-type mice
• the fibrils surrounding the edge of the tectorial membrane are severely disrupted compared to in wild-type mice
abnormal Kimura membrane morphology ( J:160851 )
• Kimura's membrane contains severely disrupted fibrils compared to in wild-type mice
abnormal cochlear outer hair cell physiology ( J:160851 )
• during acoustic stimulation of the stapes, outer hair cells in all rows exhibit no forward transduction unlike in similarly treated wild-type cells
decreased cochlear microphonics ( J:160851 )
• in response to an accoustic stimuli, cochlear microphonic is asymmetrical, reduced in amplitude, and a quarter of a cycle ahead of the stimulus unlike in wild-type mice
increased or absent threshold for auditory brainstem response ( J:160851 )
• homozygous mice had 30-50 dB ABR threshold elevations relative to wild-type littermates
impaired hearing ( J:160851 )
• mice exhibit severe hearing loss compared with wild-type mice

nervous system
abnormal cochlear outer hair cell physiology ( J:160851 )
• during acoustic stimulation of the stapes, outer hair cells in all rows exhibit no forward transduction unlike in similarly treated wild-type cells
decreased cochlear microphonics ( J:160851 )
• in response to an accoustic stimuli, cochlear microphonic is asymmetrical, reduced in amplitude, and a quarter of a cycle ahead of the stimulus unlike in wild-type mice




Genotype
MGI:4458445
hm2
Allelic
Composition		 Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic
Background		 involves: 129S7/SvEvBrd * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm1.1Ogha mutation (1 available); any Tecta mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal otoacoustic response ( J:160851 )
• electrically evoked otoacoustic emissions amplitudes are increased compared to in wild-type mice




Genotype
MGI:4458443
ht3
Allelic
Composition		 Tectatm1.1Ogha/Tecta+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm1.1Ogha mutation (1 available); any Tecta mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal tectorial membrane morphology ( J:160851 )
• the tectorial membrane is thicker and shorter than in wild-type mice but not as much as in homozygous mice
• the fibrils surrounding the edge of the tectorial membrane are partially disrupted compared to in wild-type mice
abnormal Kimura membrane morphology ( J:160851 )
• Kimura's membrane contains loosely packed fibrils compared to in wild-type mice
abnormal cochlear outer hair cell physiology ( J:160851 )
• during acoustic stimulation of the stapes, only outer hair cells in the first row exhibit forward transduction unlike in similarly treated wild-type cells
abnormal cochlear microphonics ( J:160851 )
• in response to an increasing intensity of accoustic stimuli, mice exhibit an increase in cochlear microphonic phase lead unlike in similarly treated wild-type mice
increased or absent threshold for auditory brainstem response ( J:160851 )
• heterozygous mice had 25-40 dB ABR threshold elevations relative to wild-type littermates
abnormal otoacoustic response ( J:160851 )
• mice exhibit enhanced reverse transduction compared with wild-type mice
abnormal distortion product otoacoustic emission ( J:160851 )
• distortion product otoacoustic emission exhibit elevated thresholds, reduced amplitudes, and higher slopes compared to in wild-type mice
impaired hearing ( J:160851 )
• mice exhibit partial hearing loss compared with wild-type mice

nervous system
abnormal cochlear outer hair cell physiology ( J:160851 )
• during acoustic stimulation of the stapes, only outer hair cells in the first row exhibit forward transduction unlike in similarly treated wild-type cells
abnormal cochlear microphonics ( J:160851 )
• in response to an increasing intensity of accoustic stimuli, mice exhibit an increase in cochlear microphonic phase lead unlike in similarly treated wild-type mice




Genotype
MGI:4458444
cx4
Allelic
Composition		 Slc26a5tm1Jnz/Slc26a5tm1Jnz
Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic
Background		 involves: 129S7/SvEvBrd * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc26a5tm1Jnz mutation (1 available); any Slc26a5 mutation (58 available)
Tectatm1.1Ogha mutation (1 available); any Tecta mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal otoacoustic response ( J:160851 )
• electrically evoked otoacoustic emissions amplitudes are nearly completely lost unlike in wild-type mice




Genotype
MGI:4458446
cx5
Allelic
Composition		 Slc26a5tm1Jnz/Slc26a5tm1Jnz
Tectatm1.1Ogha/Tecta+
Genetic
Background		 involves: 129S7/SvEvBrd * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc26a5tm1Jnz mutation (1 available); any Slc26a5 mutation (58 available)
Tectatm1.1Ogha mutation (1 available); any Tecta mutation (133 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal otoacoustic response ( J:160851 )
• electrically evoked otoacoustic emissions amplitudes are nearly completely lost unlike in wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory