Phenotypes associated with this allele

• Allele Symbol: Katna1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4458514
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Katna1^tm1a(KOMP)Wtsi/Katna1^tm1a(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:6401101
ht2	Katna1^tm1a(KOMP)Wtsi/Katna1^+	involves: C57BL/6J * C57BL/6N	MGI:6401102

Genotype
MGI:6401101

hm1

• Allelic Composition: Katna1^{tm1a(KOMP)Wtsi}/Katna1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:284578 )

• no viable homozygous mice were obtained out of 149 mice born; one necrotic homozygous embryo was obtained at E15 but not at later stages

Genotype
MGI:6401102

ht2

• Allelic Composition: Katna1^{tm1a(KOMP)Wtsi}/Katna1⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

behavior/neurological

behavior/neurological phenotype ( J:284578 )

N • mice show no deficits in hippocampal-dependent spatial and contextual learning and memory tasks relative to wild-type controls

cellular

abnormal neuronal precursor proliferation ( J:284578 )

• mice show delayed neuronal proliferation in the cortical neurogenic niche, with significant accumulation of neuronal progenitors at the ventricular/subventricular zone during corticogenesis

• however, no malformation or aberrant cell distribution of cortical layers II, III, IV V or VI is observed during embryonic development or at early postnatal stages

decreased neuronal precursor proliferation ( J:284578 )

• adult mice show a ~50% reduction in the number of proliferating BrdU-positive cells in the subgranular zone (SGZ) of the dentate gyrus

nervous system

nervous system phenotype ( J:284578 )

N • adult brain size and overall brain anatomy are normal; no evidence of apoptosis or neuronal degeneration is observed

N • adult mice show no deficits in long-term potentiation (LTP) at the dentate gyrus relative to wild-type controls

N • Sholl analysis of dentate gyrus granule cells revealed normal dendritic arborization

abnormal neuronal precursor proliferation ( J:284578 )

• mice show delayed neuronal proliferation in the cortical neurogenic niche, with significant accumulation of neuronal progenitors at the ventricular/subventricular zone during corticogenesis

• however, no malformation or aberrant cell distribution of cortical layers II, III, IV V or VI is observed during embryonic development or at early postnatal stages

decreased neuronal precursor proliferation ( J:284578 )

• adult mice show a ~50% reduction in the number of proliferating BrdU-positive cells in the subgranular zone (SGZ) of the dentate gyrus

abnormal dentate gyrus subgranular zone morphology ( J:284578 )

• mice exhibit an accumulation of immature doublecortin (DCX)-positive cells (neuronal precursors and newborn post-mitotic neurons) in the subgranular zone (SGZ) of the dentate gyrus during adult hippocampal neurogenesis

increased neuronal precursor cell number ( J:284578 )

• Sox2/GFAP double-immunostaining revealed a significant increase in immature type-1 neuronal precursor cells in the subgranular zone (SGZ) of the adult dentate gyrus