Phenotypes associated with this allele

• Allele Symbol: Ocstamp^{tm2a(KOMP)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4458541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ocstamp^tm2a(KOMP)Wtsi/Ocstamp^tm2a(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5788577

Genotype
MGI:5788577

hm1

• Allelic Composition: Ocstamp^{tm2a(KOMP)Wtsi}/Ocstamp^{tm2a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:233553 )

N • mice exhibit normal micro-CT skeletal parameters

abnormal osteoclast morphology ( J:233553 )

• mice exhibit small, mononuclear osteoclasts unlike wild-type mice

• however, lentiviral expression of the endogenous gene restores fusion and osteoclast numbers are normal

immune system

abnormal osteoclast morphology ( J:233553 )

• mice exhibit small, mononuclear osteoclasts unlike wild-type mice

• however, lentiviral expression of the endogenous gene restores fusion and osteoclast numbers are normal

hematopoietic system

abnormal osteoclast morphology ( J:233553 )

• mice exhibit small, mononuclear osteoclasts unlike wild-type mice

• however, lentiviral expression of the endogenous gene restores fusion and osteoclast numbers are normal