Phenotypes associated with this allele

• Allele Symbol: Sdccag8^{tm1e(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4458830
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sdccag8^tm1e(EUCOMM)Wtsi/Sdccag8^tm1e(EUCOMM)Wtsi	involves: C57BL/6	MGI:5606043

Genotype
MGI:5606043

hm1

• Allelic Composition: Sdccag8^{tm1e(EUCOMM)Wtsi}/Sdccag8^{tm1e(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6
• Cell Lines: EPD0581_2_D04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:215665 )

• most pups die after birth

nervous system

abnormal neuronal migration ( J:215665 )

• fewer cells expressing neuronal marker TBR1 (superficial neurons) are found near the bottom of the cortex than expected

• fewer cells expressing neuronal marker BRN2 (deep layer neurons)are found at the top of the cortex than expected and more cells are found near the bottom of the cortex

enlarged lateral ventricles ( J:215665 )

• enlarged lateral ventricle in 4 out 18 animals

abnormal choroid plexus morphology ( J:215665 )

digestive/alimentary system

cleft palate ( J:215665 )

• cleft palate is observed in 94% (17 or 18) mice

growth/size/body

cleft palate ( J:215665 )

• cleft palate is observed in 94% (17 or 18) mice

limbs/digits/tail

polydactyly ( J:215665 )

• polydactyly is observed in 94% (17 or 18) mice

craniofacial

cleft palate ( J:215665 )

• cleft palate is observed in 94% (17 or 18) mice

cellular

abnormal nonmotile primary cilium morphology ( J:215665 )

• decrease in length of primary cilia from E15.5 choroid plexus

abnormal neuronal migration ( J:215665 )

• fewer cells expressing neuronal marker TBR1 (superficial neurons) are found near the bottom of the cortex than expected

• fewer cells expressing neuronal marker BRN2 (deep layer neurons)are found at the top of the cortex than expected and more cells are found near the bottom of the cortex