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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Runx1-GFP)#Itan
transgene insertion, Ichiro Taniuchi
MGI:4458874
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Runx1tm3Itan/Runx1tm3Itan
Tg(Runx1-GFP)#Itan/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4459012
cx2
Runx1tm1Yg/Runx1tm1Yg
Tg(Runx1-GFP)#Itan/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4459013
cx3
Runx1tm1Yg/Runx1+
Tg(Runx1-GFP)#Itan/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4459014


Genotype
MGI:4459012
cx1
Allelic
Composition
Runx1tm3Itan/Runx1tm3Itan
Tg(Runx1-GFP)#Itan/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Itan mutation (0 available); any Runx1 mutation (34 available)
Tg(Runx1-GFP)#Itan mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit a severe decrease in GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice

hematopoietic system
• mice exhibit a severe decrease in GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice




Genotype
MGI:4459013
cx2
Allelic
Composition
Runx1tm1Yg/Runx1tm1Yg
Tg(Runx1-GFP)#Itan/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (34 available)
Tg(Runx1-GFP)#Itan mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice lack GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice
• mesenchyme beneath the dorsal aorta is compact unlike in wild-type mice

hematopoietic system
• mice lack GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice




Genotype
MGI:4459014
cx3
Allelic
Composition
Runx1tm1Yg/Runx1+
Tg(Runx1-GFP)#Itan/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (34 available)
Tg(Runx1-GFP)#Itan mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit fewer large GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice

hematopoietic system
• mice exhibit fewer large GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory