All Phenotypes Ret<tm3.1(Bcl2l1)Heno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^{tm3.1(Bcl2l1)Heno}
targeted mutation 3.1, Hideki Enomoto
MGI:4459031

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ret^{tm3.1(Bcl2l1)Heno}/Ret⁺	involves: 129/Sv * C57BL/6	MGI:4459059
ht2	Ret^tm2(RET)Heno/Ret^{tm3.1(Bcl2l1)Heno}	involves: 129/Sv * C57BL/6	MGI:4459058
ht3	Ret^tm2(RET)Jmi/Ret^{tm3.1(Bcl2l1)Heno}	involves: 129/Sv * C57BL/6	MGI:4459064
cn4	Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459061
cn5	Bax^tm1Sjk/Bax^tm1Sjk Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459062

Allelic Composition	Ret^{tm3.1(Bcl2l1)Heno}/Ret⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:159854 )

N	• mice exhibit normal numbers of neurons in the small intestine and colon

decreased neuron apoptosis ( J:159854 )

• enteric neurons are protected from GDNF-induced apoptosis compared with similarly treated wild-type neurons

digestive/alimentary system

digestive/alimentary phenotype ( J:159854 )

N	• mice exhibit normal numbers of neurons in the small intestine and colon

cellular

decreased neuron apoptosis ( J:159854 )

• enteric neurons are protected from GDNF-induced apoptosis compared with similarly treated wild-type neurons

Allelic Composition	Ret^tm2(RET)Heno/Ret^{tm3.1(Bcl2l1)Heno}
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (54 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent enteric neurons ( J:159854 )

renal/urinary system

absent kidney ( J:159854 )

Allelic Composition	Ret^tm2(RET)Jmi/Ret^{tm3.1(Bcl2l1)Heno}
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2(RET)Jmi mutation (0 available); any Ret mutation (54 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:159854 )

N	• mice exhibit improved survival compared with Ret^tm1Heno/Ret^tm2(RET)Jmi mice

digestive/alimentary system

digestive/alimentary phenotype ( J:159854 )

N	• gut motility is normal

nervous system

absent enteric neurons ( J:159854 )

• 1 of 51 mice exhibit aganglionosis compared with wild-type mice

• however, 50 of 51 mice exhibit normal enteric nervous system

embryo

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

cellular

abnormal enteric neural crest cell migration ( J:159854 )

• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

Allelic Composition	Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (54 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased feces water content ( J:159854 )

• tamoxifen-treated mice exhibit wet stool weight and water stool content compared with control mice

abnormal defecation ( J:159854 )

• tamoxifen-treated mice exhibit decreased stool frequency compared with control mice

• 2 to 5 tamoxifen-treated mice exhibit hard feces that accumulates in the distal colon unlike in control mice

growth/size/body

decreased body weight ( J:159854 )

• in tamoxifen-treated mice

nervous system

abnormal enteric neuron morphology ( J:159854 )

• 40% of tamoxifen-treated mice exhibit reduced enteric neurons compared with similarly treated control mice (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

• tamoxifen-treated mice exhibit fewer NOS-expressing neurons compared to in control mice

• however, 60% of tamoxifen-treated mice exhibit normal enteric nervous system development

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ret^tm1Heno mutation (0 available); any Ret mutation (54 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:159854 )

• tamoxifen-treated mice exhibit loss of enteric neurons unlike similarly treated control mice (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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