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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Esr1tm1Sakh
targeted mutation 1, Sohaib A Khan
MGI:4459300
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Esr1tm1Sakh/Esr1tm1Sakh
Tg(MMTV-cre)4Mam/? 		involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:4459316
cn2
 		Esr1tm1Sakh/Esr1tm1Sakh
Tg(Wap-cre)11738Mam/? 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4459317


Genotype
MGI:4459316
cn1
Allelic
Composition		 Esr1tm1Sakh/Esr1tm1Sakh
Tg(MMTV-cre)4Mam/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Sakh mutation (0 available); any Esr1 mutation (68 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:124962 )
• mammary ductal outgrowth arrested at prepubertal stage
• little ductal invasion of fat pad at 6 months
• minimal side branching

integument
abnormal branching of the mammary ductal tree ( J:124962 )
• mammary ductal outgrowth arrested at prepubertal stage
• little ductal invasion of fat pad at 6 months
• minimal side branching




Genotype
MGI:4459317
cn2
Allelic
Composition		 Esr1tm1Sakh/Esr1tm1Sakh
Tg(Wap-cre)11738Mam/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Sakh mutation (0 available); any Esr1 mutation (68 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:124962 )
• mosaic mammary gland phenotype in the first lactation
abnormal branching of the mammary ductal tree ( J:124962 )
• mild defect in tertiary branching during first lactation
• aberrantly dilated ducts with few side branches during second lactation
abnormal mammary gland alveolus morphology ( J:124962 )
• some normal sized alveoli in first lactation
• regions of reduced growth in the first lactation
• fewer lobular alveoli during second lactation
abnormal lactation ( J:124962 )
• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days
• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days
• normal milk quality

integument
abnormal mammary gland morphology ( J:124962 )
• mosaic mammary gland phenotype in the first lactation
abnormal branching of the mammary ductal tree ( J:124962 )
• mild defect in tertiary branching during first lactation
• aberrantly dilated ducts with few side branches during second lactation
abnormal mammary gland alveolus morphology ( J:124962 )
• fewer lobular alveoli during second lactation
• some normal sized alveoli in first lactation
• regions of reduced growth in the first lactation
abnormal lactation ( J:124962 )
• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days
• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days
• normal milk quality




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory