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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il13tm1(YFP/cre)Lky
targeted mutation 1, Richard M Locksley
MGI:4459318
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5435902
cn2
 		Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5435903
cn3
 		Gata3tm1Iho/Gata3tm1Iho
Il13tm1(YFP/cre)Lky/Il13+ 		involves: 129S4/SvJae MGI:5435904


Genotype
MGI:5435902
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
decreased IgG1 level ( J:178986 )
• slightly less in an anti-NP response
decreased interleukin-13 secretion ( J:178986 )
• in lung CD4+ T cells of mice infected with N. brasiliensis
decreased interleukin-5 secretion ( J:178986 )
• in lung CD4+ T cells of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice fail to expel the helminth Nippostrongylus brasiliensis

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
decreased IgG1 level ( J:178986 )
• slightly less in an anti-NP response




Genotype
MGI:5435903
cn2
Allelic
Composition		 Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (30 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice exhibit reduced helminthes Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis




Genotype
MGI:5435904
cn3
Allelic
Composition		 Gata3tm1Iho/Gata3tm1Iho
Il13tm1(YFP/cre)Lky/Il13+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Iho mutation (0 available); any Gata3 mutation (32 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice exhibit reduced helminth Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory